Art

J-GLOBAL ID：201902255832372382   Reference number：19A1861510

Anti-RelA siRNA-Encapsulated Flexible Liposome with Tight Junction-Opening Peptide as a Non-invasive Topical Therapeutic for Atopic Dermatitis

アトピー性皮膚炎に対する非侵襲性局所治療薬としてのタイトジャンクション開口ペプチドを持つ抗RelA siRNA封入柔軟可動性リポソーム

Author (8)： Ibaraki Hisako (School of Pharmacy, Tokyo University of Pharmacy and Life Sciences) ,  Kanazawa Takanori (School of Pharmacy, Tokyo University of Pharmacy and Life Sciences) ,  Kanazawa Takanori (School of Pharmacy, Nihon University) ,  Kurano Takumi (School of Pharmacy, Tokyo University of Pharmacy and Life Sciences) ,  Kurano Takumi (School of Pharmacy, Nihon University) ,  Oogi Chihiro (School of Pharmacy, Tokyo University of Pharmacy and Life Sciences) ,  Takashima Yuuki (School of Pharmacy, Tokyo University of Pharmacy and Life Sciences) ,  Seta Yasuo (School of Pharmacy, Tokyo University of Pharmacy and Life Sciences)
Material： Biological and Pharmaceutical Bulletin (Web)
Volume： 42  Issue： 7  Page： 1216-1225(J-STAGE)  Publication year： 2019 
JST Material Number： U1402A  ISSN： 1347-5215  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： mouse(animal) ,...
Semi thesaurus term： *relA gene ,...

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Author keywords (12)： atopic dermatitis ,  small interfering RNA (siRNA) ,  RelA ,  topical siRNA application ,  liposome ,  AT1002 peptide ,  atopic dermatitis ,  small interfering RNA (siRNA) ,  RelA ,  topical siRNA application ,  liposome ,  AT1002 peptide

JST classification (3)： Basic dermatology  (GF01020Y) ,  Liquid preparations  (GY02020K) ,  Biological function  (EB03040U)

Reference (45)：

• 1) Flohr C, Mann J. New insights into the epidemiology of childhood atopic dermatitis. Allergy, 69, 3-16 (2014).
• 2) Leung DY. New insights into atopic dermatitis: role of skin barrier and immune dysregulation. Allergol. Int., 62, 151-161 (2013).
• 3) Hajar T, Gontijo JRV, Hanifin JM. New and developing therapies for atopic dermatitis. An. Bras. Dermatol., 93, 104-107 (2018).
• 4) Seegräber M, Srour J, Walter A, Knop M, Wollenberg A. Dupilumab for treatment of atopic dermatitis. Expert Rev. Clin. Pharmacol., 11, 467-474 (2018).
• 5) Leung DY. Atopic dermatitis: new insights and opportunities for therapeutic intervention. J. Allergy Clin. Immunol., 105, 860-876 (2000).

Terms in the title (10)： アトピー性皮膚炎 ,  非侵襲性 ,  局所治療 ,  タイトジャンクション ,  ペプチド ,  RelA ,  siRNA ,  封入 ,  可動性 ,  リポソーム