Art

J-GLOBAL ID：201902256423928037   Reference number：19A0490555

Novel Mechanisms of ALK Activation Revealed by Analysis of the Y1278S Neuroblastoma Mutation

Y1278S神経芽細胞腫変異の分析により明らかにされたALK活性化の新規機構【JST・京大機械翻訳】

Author (7)： Guan Jikui (Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology, Sahlgrenska Academy, University of Gothenburg, SE-40530 Goteborg, Sweden) ,  Yamazaki Yasuo (Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology, Sahlgrenska Academy, University of Gothenburg, SE-40530 Goteborg, Sweden) ,  Chand Damini (Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology, Sahlgrenska Academy, University of Gothenburg, SE-40530 Goteborg, Sweden) ,  Dijk Jesper R. van (Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology, Sahlgrenska Academy, University of Gothenburg, SE-40530 Goteborg, Sweden) ,  Ruuth Kristina (Department of Molecular Biology, Umea universtiy, SE-901-87 Umea, Sweden) ,  Palmer Ruth H. (Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology, Sahlgrenska Academy, University of Gothenburg, SE-40530 Goteborg, Sweden) ,  Hallberg Bengt (Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology, Sahlgrenska Academy, University of Gothenburg, SE-40530 Goteborg, Sweden)
Material： Cancers (Web)
Volume： 9  Issue： 11  Page： 149  Publication year： 2017 
JST Material Number： U7153A  ISSN： 2072-6694  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Numerous mutations have been o...

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Thesaurus term： mutation ,  *neuroblastoma ,  oncogene ,  receptor ,  cell culture ,  characterization ,  interaction ,  receptor tyrosine kinase ,  amino acid ,  reproductive cell ,  fusion protein ,  *variation(biology) ,  phenolic compound ,  primary amine
Semi thesaurus term： キイロショウジョウバエ ,  キナーゼ , 【Automatic Indexing@JST】

Author keywords (9)： ALK ,  kinase activation ,  activation loop ,  gain-of-function ,  mutation analyses ,  Insulin receptor ,  NPM-ALK ,  oncogene ,  neuroblastoma

JST classification (2)： Genetic variation  (EC01030Y) ,  Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N)

Substance index (1)： Tyrosine

Reference (34)：

• Morris, S.W.; Kirstein, M.N.; Valentine, M.B.; Dittmer, K.G.; Shapiro, D.N.; Saltman, D.L.; Look, A.T. Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin’s Lymphoma. Science 1994, 263, 1281-1284.
• Shiota, M.; Nakamura, S.; Ichinohasama, R.; Abe, M.; Akagi, T.; Takeshita, M.; Mori, N.; Fujimoto, J.; Miyauchi, J.; Mikata, A.; et al. Anaplastic large cell lymphomas expressing the novel chimeric protein p80NPM/ALK: A distinct clinicopathologic entity. Blood 1995, 86, 1954-1960.
• Hallberg, B.; Palmer, R.H. Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology. Nat. Rev. Cancer 2013, 13, 685-700.
• Brodeur, G.M. Neuroblastoma: Biological insights into a clinical enigma. Nat. Rev. Cancer 2003, 3, 203-216.
• Hallberg, B.; Palmer, R.H. The role of the ALK receptor in cancer biology. Ann. Oncol. 2016, 27, iii4-iii15.

Terms in the title (5)： 神経芽細胞腫 ,  変異 ,  分析 ,  ALK ,  活性化