Art

J-GLOBAL ID：201902261657348948   Reference number：19A2655714

Inflammasome Activation Induced by Perfringolysin O of Clostridium perfringens and Its Involvement in the Progression of Gas Gangrene

Clostridium perfringensのperfrゴリシンOにより誘導されるインフラマソーム活性化とガス壊その進行におけるその関与【JST・京大機械翻訳】

Author (9)： Yamamura Kiyonobu (Department of Bacterial Pathogenesis, Infection and Host Response, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan) ,  Ashida Hiroshi (Department of Bacterial Pathogenesis, Infection and Host Response, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan) ,  Okano Tokuju (Department of Bacterial Pathogenesis, Infection and Host Response, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan) ,  Kinoshita-Daitoku Ryo (Department of Bacterial Pathogenesis, Infection and Host Response, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan) ,  Suzuki Shiho (Department of Bacterial Pathogenesis, Infection and Host Response, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan) ,  Ohtani Kaori (Department of Bacteriology and Bacterial Infection, Division of Host Defense Mechanism, Tokai University School of Medicine, Isehara, Japan) ,  Hamagaki Miwako (Department of Oral Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan) ,  Ikeda Tohru (Department of Oral Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan) ,  Suzuki Toshihiko (Department of Bacterial Pathogenesis, Infection and Host Response, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan)
Material： Frontiers in Microbiology (Web)
Volume： 10  Page： 2406  Publication year： 2019 
JST Material Number： U7080A  ISSN： 1664-302X  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Clostridium perfringens (C. pe...

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Thesaurus term： pathogenesis ,  toxin ,  *gas gangrene ,  *Welch bacillus ,  protein ,  culture(biology) ,  receptor ,  pathogen ,  caspase ,  *Clostridium
Semi thesaurus term： 炎症反応 ,  筋壊死 ,  インターロイキン1β ,  αトキシン ,  *インフラマソーム , 【Automatic Indexing@JST】

Author keywords (5)： Clostridium perfringens ,  gas gangrene ,  inflammasome ,  caspase-1 ,  perfringolysin O

JST classification (1)： Physiology and pathogenicity of microbial infection  (EG03053T)

Reference (34)：

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• Awad M. M., Ellemor D. M., Boyd R. L., Emmins J. J., Rood J. I. (2001). Synergistic effects of alpha-toxin and perfringolysin O in Clostridium perfringens-mediated gas gangrene. Infect. Immun. 69 7904-7910. doi: 10.1128/IAI.69.12.7904-7910.2001
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• Bryant A. E., Chen R. Y., Nagata Y., Wang Y., Lee C. H., Finegold S., et al (2000a). Clostridial gas gangrene. I. Cellular and molecular mechanisms of microvascular dysfunction induced by exotoxins of Clostridium perfringens. J. Infect. Dis. 182 799-807. doi: 10.1086/315756

Terms in the title (5)： Clostridium ,  誘導 ,  インフラマソーム ,  活性化 ,  ガス壊そ