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J-GLOBAL ID：201902265943812060   Reference number：19A1341683

Anticancer saponin OSW-1 is a novel class of selective Golgi stress inducer

抗癌サポニンOSW-1は選択的ゴルジストレス誘導因子の新規クラスである【JST・京大機械翻訳】

Author (7)： Kimura Mayu (Department of Biotechnology and Life Science, Faculty of Engineering, Tokyo University of Agriculture and Technology, 2-24-18, Naka-cho, Koganei-shi, Tokyo 184-8588, Japan) ,  Sasaki Kanae (Department of Biochemistry and Molecular Biology, Graduate School of Life Science, University of Hyogo, Harima Science Garden City, Hyogo 678-1297, Japan) ,  Fukutani Yosuke (Department of Biotechnology and Life Science, Faculty of Engineering, Tokyo University of Agriculture and Technology, 2-24-18, Naka-cho, Koganei-shi, Tokyo 184-8588, Japan) ,  Yoshida Hiderou (Department of Biochemistry and Molecular Biology, Graduate School of Life Science, University of Hyogo, Harima Science Garden City, Hyogo 678-1297, Japan) ,  Ohsawa Ikuroh (Biological Process of Aging, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan) ,  Yohda Masafumi (Department of Biotechnology and Life Science, Faculty of Engineering, Tokyo University of Agriculture and Technology, 2-24-18, Naka-cho, Koganei-shi, Tokyo 184-8588, Japan) ,  Sakurai Kaori (Department of Biotechnology and Life Science, Faculty of Engineering, Tokyo University of Agriculture and Technology, 2-24-18, Naka-cho, Koganei-shi, Tokyo 184-8588, Japan)
Material： Bioorganic & Medicinal Chemistry Letters  (Bioorg Med Chem Lett)
Volume： 29  Issue： 14  Page： 1732-1736  Publication year： 2019 
JST Material Number： W0248A  ISSN： 0960-894X  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： OSW-1 is a plant-derived natur...

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Thesaurus term： apoptosis ,  tumor cell ,  antitumor action ,  *saponin ,  lipid ,  cell death ,  natural material
Semi thesaurus term： ストレス応答 ,  蛋白質リガンド相互作用 ,  オキシステロール結合蛋白質 , 【Automatic Indexing@JST】

Author keywords (5)： OSW-1 ,  Anticancer natural product ,  Golgi stress response ,  OSBP ,  Saponin

JST classification (5)： Synthesis of drugs  (GV01030F) ,  Plant biochemistry  (EH01050J) ,  Condensed derivatives of pyrane  (CF07093I) ,  Crude drugs in general  (GX06010Y) ,  Structure-activity relationship of drugs  (GV01050B)

Substance index (1)： OSW-1

Terms in the title (6)： 癌 ,  サポニン ,  OSW-1 ,  誘導 ,  因子 ,  クラス