Art

J-GLOBAL ID：201902266054243367   Reference number：19A1207642

An Engineered Aryl Acid Adenylation Domain with an Enlarged Substrate Binding Pocket

拡大基質結合ポケットを有する改変アリール酸アデニル化ドメイン【JST・京大機械翻訳】

Author (8)： Ishikawa Fumihiro (Faculty of Pharmacy, Kindai University, 3-4-1 Kowakae, Higashi-Osaka, Osaka 577-, 8502, Japan) ,  Miyanaga Akimasa (Department of Chemistry, Tokyo Institute of Technology, 2-12-1 O-okayama, Meguro-ku, Tokyo, 152-8551, Japan) ,  Kitayama Hinano (Faculty of Pharmacy, Kindai University, 3-4-1 Kowakae, Higashi-Osaka, Osaka 577-, 8502, Japan) ,  Nakamura Shinya (Faculty of Pharmacy, Kindai University, 3-4-1 Kowakae, Higashi-Osaka, Osaka 577-, 8502, Japan) ,  Nakanishi Isao (Faculty of Pharmacy, Kindai University, 3-4-1 Kowakae, Higashi-Osaka, Osaka 577-, 8502, Japan) ,  Kudo Fumitaka (Department of Chemistry, Tokyo Institute of Technology, 2-12-1 O-okayama, Meguro-ku, Tokyo, 152-8551, Japan) ,  Eguchi Tadashi (Department of Chemistry, Tokyo Institute of Technology, 2-12-1 O-okayama, Meguro-ku, Tokyo, 152-8551, Japan) ,  Tanabe Genzoh (Faculty of Pharmacy, Kindai University, 3-4-1 Kowakae, Higashi-Osaka, Osaka 577-, 8502, Japan)
Material： Angewandte Chemie. International Edition  (Angewandte Chemie. International Edition in English)
Volume： 58  Issue： 21  Page： 6906-6910  Publication year： 2019 
JST Material Number： H0127B  ISSN： 1433-7851  CODEN： ACIEAY  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Abstract/Point： Adenylation (A) domains act as...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=19A1207642&from=J-GLOBAL&jstjournalNo=H0127B") }}

Thesaurus term： chelation ,  *binding site ,  catalyst ,  synthase ,  biosynthesis ,  wild type ,  siderophore ,  *substrate (biochemistry) ,  functionalization ,  enzyme ,  natural material ,  thioesterification ,  nonribosomal peptide ,  *adenylation ,  amino acid ,  aliphatic amine ,  aliphatic carboxylic acid

Author keywords (5)： adenylation domain ,  biosynthesis ,  enzyme engineering ,  non-ribosomal peptide synthetases ,  structural biology

JST classification (2)： Addition reaction,elimination reaction  (CF02030M) ,  Platinum family element complexes  (CE01100E)

Substance index (1)： Glycine

Terms in the title (7)： 拡大 ,  基質 ,  結合ポケット ,  改変 ,  酸 ,  アデニル化 ,  ドメイン