Art

J-GLOBAL ID：201902268115225303   Reference number：19A1547911

Molecular Consequences of the Myopathy-Related D286G Mutation on Actin Function

アクチン機能におけるミオパチー関連D286G変異の分子的結果【JST・京大機械翻訳】

Author (9)： Fan Jun (Department of Physics and Materials Science, The University of Hong Kong, Hong Kong, Hong Kong) ,  Fan Jun (City University of Hong Kong Shenzhen Research Institute, Shenzhen, China) ,  Chan Chun (Department of Physics and Materials Science, The University of Hong Kong, Hong Kong, Hong Kong) ,  McNamara Elyshia L. (Harry Perkins Institute of Medical Research, QEII Medical Centre, The University of Western Australia, Nedlands, WA, Australia) ,  Nowak Kristen J. (Harry Perkins Institute of Medical Research, QEII Medical Centre, The University of Western Australia, Nedlands, WA, Australia) ,  Nowak Kristen J. (Department of Health, Office of Population Health Genomics, Public and Aboriginal Health Division, Government of Western Australia, East Perth, WA, Australia) ,  Nowak Kristen J. (School of Biomedical Sciences, Faculty of Health and Medical Sciences, The University of Western Australia, Crawley, WA, Australia) ,  Iwamoto Hiroyuki (SPring-8, Japan Synchrotron Radiation Research Institute, Sayo, Japan) ,  Ochala Julien (School of Basic and Medical Biosciences, Faculty of Life Sciences and Medicine, King’s College London, London, United Kingdom)
Material： Frontiers in Physiology (Web)
Volume： 9  Page： 1756  Publication year： 2018 
JST Material Number： U7093A  ISSN： 1664-042X  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Myopathies are notably associa...

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Thesaurus term： skeletal muscle ,  *actin ,  muscle fiber ,  Phenotype ,  actin filament ,  Mutation ,  *muscular disease ,  flexural rigidity ,  dysfunction ,  interface (surface) ,  gene ,  Molecular Dynamics Simulation ,  ex vivo experiment ,  molecular mechanism ,  *Genetic Variation
Semi thesaurus term： *variation(biology) , 【Automatic Indexing@JST】

Author keywords (5)： actin mutation ,  myopathy ,  muscle force ,  actin mechanics ,  muscle fiber

JST classification (2)： Basic medicine on cardiovascular system  (GJ01020K) ,  Cardiovascular system diseases  (GJ03000C)

Reference (29)：

• Chan C., Fan J., Messer A. E., Marston S. B., Iwamoto H., Ochala J. (2016). Myopathy-inducing mutation H40Y in ACTA1 hampers actin filament structure and function. Biochim. Biophys. Acta 1862 1453-1458. doi: 10.1016/j.bbadis.2016.04.013
• Dominguez R., Holmes K. C. (2011). Actin structure and function. Annu. Rev. Biophys. 40 169-186. doi: 10.1146/annurev-biophys-042910-155359
• Fan J., Saunders M. G., Haddadian E. J., Freed K. F., De La Cruz E. M., Voth G. A. (2013). Molecular origins of cofilin-linked changes in actin filament mechanics. J. Mol. Biol. 425 1225-1240. doi: 10.1016/j.jmb.2013.01.020
• Fan J., Saunders M. G., Voth G. A. (2012). Coarse-graining provides insights on the essential nature of heterogeneity in actin filaments. Biophys. J. 103 1334-1342. doi: 10.1016/j.bpj.2012.08.029
• Frenkel B., Smit B. (2002). Understanding Molecular Simulation: From Algorithms to Applications, 2nd Edn. Cambridge: Academic Press. doi: 10.1016/j.bpj.2012.08.029

Terms in the title (4)： アクチン ,  ミオパチー ,  変異 ,  分子