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J-GLOBAL ID：201902268664392362   Reference number：19A1206485

An Engineered Aryl Acid Adenylation Domain with an Enlarged Substrate Binding Pocket

拡大基質結合ポケットを有する改変アリール酸アデニル化ドメイン【JST・京大機械翻訳】

Author (8)： Ishikawa Fumihiro (Faculty of Pharmacy, Kindai University, 3-4-1 Kowakae, Higashi-Osaka, Osaka 577-, 8502, Japan) ,  Miyanaga Akimasa (Department of Chemistry, Tokyo Institute of Technology, 2-12-1 O-okayama, Meguro-ku, Tokyo, 152-8551, Japan) ,  Kitayama Hinano (Faculty of Pharmacy, Kindai University, 3-4-1 Kowakae, Higashi-Osaka, Osaka 577-, 8502, Japan) ,  Nakamura Shinya (Faculty of Pharmacy, Kindai University, 3-4-1 Kowakae, Higashi-Osaka, Osaka 577-, 8502, Japan) ,  Nakanishi Isao (Faculty of Pharmacy, Kindai University, 3-4-1 Kowakae, Higashi-Osaka, Osaka 577-, 8502, Japan) ,  Kudo Fumitaka (Department of Chemistry, Tokyo Institute of Technology, 2-12-1 O-okayama, Meguro-ku, Tokyo, 152-8551, Japan) ,  Eguchi Tadashi (Department of Chemistry, Tokyo Institute of Technology, 2-12-1 O-okayama, Meguro-ku, Tokyo, 152-8551, Japan) ,  Tanabe Genzoh (Faculty of Pharmacy, Kindai University, 3-4-1 Kowakae, Higashi-Osaka, Osaka 577-, 8502, Japan)
Material： Angewandte Chemie  (Angew Chem)
Volume： 131  Issue： 21  Page： 6980-6984  Publication year： 2019 
JST Material Number： A0396A  ISSN： 0044-8249  CODEN： ANCEAD  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Adenylation (A) domains act as...

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Thesaurus term： functionalization ,  *substrate (biochemistry) ,  biosynthesis ,  chelation ,  wild type ,  natural material ,  catalyst ,  *binding site ,  synthase ,  siderophore ,  thioesterification ,  nonribosomal peptide ,  *adenylation ,  amino acid ,  aliphatic amine ,  aliphatic carboxylic acid ,  carboxamide ,  dicarboxylic acid ,  primary amine

Author keywords (5)： Adenylierungsdomaene ,  Biosynthese ,  Enzym-Engineering ,  Nichtribosomale Peptid-Synthetasen ,  Strukturbiologie

JST classification (2)： Addition reaction,elimination reaction  (CF02030M) ,  Cyclization reaction,ring-opening reaction  (CF02050I)

Substance index (2)： Glycine ,  Asparagine

Terms in the title (7)： 拡大 ,  基質 ,  結合ポケット ,  改変 ,  酸 ,  アデニル化 ,  ドメイン