Art

J-GLOBAL ID：201902268906139418   Reference number：19A1419658

Burosumab versus conventional therapy in children with X-linked hypophosphataemia: a randomised, active-controlled, open-label, phase 3 trial

X連鎖低リン酸血症の小児におけるブロスマブ対従来の治療:無作為化,アクティブ制御,オープンラベル,第3相試験【JST・京大機械翻訳】

Author (27)： Imel Erik A (Department of Medicine and Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA) ,  Glorieux Francis H (Shriners Hospital for Children - Canada, McGill University, Montreal, QC, Canada) ,  Whyte Michael P (Shriners Hospitals for Children - St Louis, St Louis, MO, USA) ,  Munns Craig F (The University of Sydney Children’s Hospital Westmead Clinical School, The Children’s Hospital at Westmead, Westmead, NSW, Australia) ,  Munns Craig F (Department of Endocrinology, The Children’s Hospital at Westmead, Westmead, NSW, Australia) ,  Ward Leanne M (Department of Pediatrics, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada) ,  Nilsson Ola (Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden) ,  Nilsson Ola (School of Medical Sciences, OErebro University, OErebro, Sweden) ,  Simmons Jill H (Department of Pediatrics, Division of Endocrinology and Diabetes, Vanderbilt University School of Medicine, Vanderbilt University, Nashville, TN, USA) ,  Padidela Raja (Department of Paediatric Endocrinology, Royal Manchester Children’s Hospital, Manchester, UK) ,  Namba Noriyuki (Department of Pediatrics, Osaka Hospital, Japan Community Healthcare Organization, Osaka, Japan) ,  Namba Noriyuki (Department of Pediatrics, Osaka University Graduate School of Medicine, Osaka, Japan) ,  Cheong Hae Il (Seoul National University Children’s Hospital, Seoul, Korea) ,  Pitukcheewanont Pisit (Center of Endocrinology, Diabetes and Metabolism, Children’s Hospital of Los Angeles, Los Angeles, CA, USA) ,  Sochett Etienne (Department of Pediatrics, Hospital for Sick Children, Toronto, ON, Canada) ,  Hogler Wolfgang (Department of Paediatrics and Adolescent Medicine, Johannes Kepler University Linz, Linz, Austria) ,  Hogler Wolfgang (Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK) ,  Muroya Koji (Kanagawa Children’s Medical Center, Yokohama, Japan) ,  Tanaka Hiroyuki (Okayama Saiseikai General Hospital Outpatient Center, Okayama, Japan) ,  Gottesman Gary S (Shriners Hospitals for Children - St Louis, St Louis, MO, USA) ,  Biggin Andrew (The University of Sydney Children’s Hospital Westmead Clinical School, The Children’s Hospital at Westmead, Westmead, NSW, Australia) ,  Perwad Farzana (Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA) ,  Mao Meng (Ultragenyx Pharmaceutical, Novato, CA, USA) ,  Chen Chao-Yin (Ultragenyx Pharmaceutical, Novato, CA, USA) ,  Skrinar Alison (Ultragenyx Pharmaceutical, Novato, CA, USA) ,  San Martin Javier (Ultragenyx Pharmaceutical, Novato, CA, USA) ,  Portale Anthony A (Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA)
Material： Lancet
Volume： 393  Issue： 10189  Page： 2416-2427  Publication year： 2019 
JST Material Number： B0673A  ISSN： 0140-6736  CODEN： LANCA  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： X-linked hypophosphataemia in ...

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Thesaurus term： safety ,  *therapy ,  mutation ,  *child ,  effectiveness ,  *phase 3 study ,  least squares method ,  *phosphoric acid ,  human(primates) ,  monoclonal antibody
Semi thesaurus term： 有害事象 ,  少女 ,  スコア ,  エンドポイント ,  エンドペプチダーゼ , 【Automatic Indexing@JST】

JST classification (1)： Drug therapy(=pharmacotherapy)for nervous system diseases  (GN05020Y)

Terms in the title (7)： 低リン酸血症 ,  小児 ,  ブロスマブ ,  治療 ,  アクティブ制御 ,  ラベル ,  第3相試験