Art

J-GLOBAL ID：201902268953074622   Reference number：19A2206527

2,5-Dimethylcelecoxib prevents isoprenaline-induced cardiomyocyte hypertrophy and cardiac fibroblast activation by inhibiting Akt-mediated GSK-3 phosphorylation

2,5-ジメチルセレコキシブはAkt仲介GSK-3リン酸化を阻害することによりイソプレナリン誘導心筋細胞肥大と心臓線維芽細胞活性化を防ぐ【JST・京大機械翻訳】

Author (10)： Morishige Shoji (Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan) ,  Morishige Shoji (Department of Cardiovascular Surgery, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan) ,  Takahashi-Yanaga Fumi (Department of Pharmacology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan) ,  Ishikane Shin (Department of Pharmacology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan) ,  Arioka Masaki (Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan) ,  Igawa Kazunobu (Department of Molecular and Material Science, Institute for Materials Chemistry and Engineering, Kyushu University, Fukuoka, Japan) ,  Kuroo Akihiro (Department of Molecular and Material Science, Institute for Materials Chemistry and Engineering, Kyushu University, Fukuoka, Japan) ,  Tomooka Katsuhiko (Department of Molecular and Material Science, Institute for Materials Chemistry and Engineering, Kyushu University, Fukuoka, Japan) ,  Shiose Akira (Department of Cardiovascular Surgery, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan) ,  Sasaguri Toshiyuki (Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan)
Material： Biochemical Pharmacology  (Biochem Pharmacol)
Volume： 168  Page： 82-90  Publication year： 2019 
JST Material Number： B0128A  ISSN： 0006-2952  CODEN： BCPCA6  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： We previously reported that 2,...

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Thesaurus term： cardiac insufficiency ,  heredity ,  *myocardium ,  *cardiac myocyte ,  rat ,  fibronectin ,  phosphatase ,  *phosphorylation ,  enzyme inhibitor
Semi thesaurus term： テンシン ,  βカテニン ,  心臓リモデリング ,  シクロオキシゲナーゼ2 ,  *Akt/蛋白質キナーゼB ,  *グリコーゲンシンターゼキナーゼ3 , 【Automatic Indexing@JST】

Author keywords (5)： 2 5-Dimethylcelecoxib ,  Akt ,  GSK-3 ,  Cardiomyocytes ,  Cardiac fibroblasts

JST classification (1)： Basic research of cardioactive drugs  (GW07020N)

Substance index (1)： Celecoxib

Terms in the title (10)： Akt ,  仲介 ,  GSK-3 ,  リン酸化 ,  阻害 ,  イソプレナリン ,  誘導 ,  心筋細胞肥大 ,  心臓線維芽細胞 ,  活性化