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J-GLOBAL ID：201902270966709070   Reference number：19A1589665

Gene Expression and Methylation Analysis in Melanomas and Melanocytes From the Same Patient: Loss of NPM2 Expression Is a Potential Immunohistochemical Marker for Melanoma

同一患者からの黒色腫とメラニン細胞における遺伝子発現とメチル化分析:メラノーマに対する潜在的免疫組織化学マーカーであるNPM2発現の消失【JST・京大機械翻訳】

Author (7)： Fujiwara Susumu (Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine, Chuo-ku, Japan) ,  Nagai Hiroshi (Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine, Chuo-ku, Japan) ,  Jimbo Haruki (Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine, Chuo-ku, Japan) ,  Jimbo Naoe (Department of Diagnostic Pathology, Kobe University Graduate School of Medicine, Chuo-ku, Japan) ,  Tanaka Tomoyo (R&D Department, Japan Tissue Engineering Co., Ltd, Gamagori, Japan) ,  Inoie Masukazu (R&D Department, Japan Tissue Engineering Co., Ltd, Gamagori, Japan) ,  Nishigori Chikako (Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine, Chuo-ku, Japan)
Material： Frontiers in Oncology (Web)
Volume： 8  Page： 675  Publication year： 2018 
JST Material Number： U7089A  ISSN： 2234-943X  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： DNA methylation is considered ...

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Thesaurus term： Down-Regulation ,  *human ,  clustering ,  *Methylation ,  *Melanocytes ,  *Melanoma ,  *gene expression ,  epithelium ,  *immunohistochemistry ,  culture (biology) ,  clade ,  melanoma cell ,  DNA Methylation ,  immune response ,  modification ,  *molecular genetic phenomenon ,  membrane and film ,  histomembrane
Semi thesaurus term： immunological reaction ,  診療 ,  病巣 , 【Automatic Indexing@JST】

Author keywords (6)： melanoma ,  melanocyte ,  nevi ,  epigenetics ,  methylation ,  NPM2

JST classification (2)： Gene expression  (EC02040Q) ,  Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N)

Reference (18)：

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• Sarkar D, Leung EY, Baguley BC, Finlay GJ, Askarian-Amiri ME. Epigenetic regulation in human melanoma: past and future. Epigenetics (2015) 10:103-21. doi: 10.1080/15592294.2014.1003746
• Nandakumar V, Vaid M, Tollefsbol TO, Katiyar SK. Aberrant DNA hypermethylation patterns lead to transcriptional silencing of tumor suppressor genes in UVB-exposed skin and UVB-induced skin tumors of mice. Carcinogenesis (2011) 32:597-604. doi: 10.1093/carcin/bgq282
• Salvaing J, Peynot N, Bedhane MN, Veniel S, Pellier E, Boulesteix C, et al. Assessment of 'one-step' vs. 'sequential' embryo culture conditions through embryonic genome methylation and hydroxymethylation changes. Hum Reprod. (2017) 32:967. doi: 10.1093/humrep/dex020
• Chen H, Zheng Z, Kim KY, Jin X, Roh MR, Jin Z. Hypermethylation and downregulation of glutathione peroxidase 3 are related to pathogenesis of melanoma. Oncol Rep. (2016) 36:2737-44. doi: 10.3892/or.2016.5071

Terms in the title (10)： 患者 ,  黒色腫 ,  メラニン細胞 ,  遺伝子発現 ,  メチル化 ,  分析 ,  メラノーマ ,  免疫組織化学 ,  マーカー ,  発現