Art
J-GLOBAL ID：201902272200594695   Reference number：19A2653400

Brain Targeting of Acyl-CoA:Cholesterol O-Acyltransferase-1 Inhibitor K-604 via the Intranasal Route Using a Hydroxycarboxylic Acid Solution

ヒドロキシカルボン酸溶液を用いた鼻内経路によるアシル-CoA:コレステロールO-アシルトランスフェラーゼ-1阻害剤K-604の脳標的化【JST・京大機械翻訳】
Author (7)：
Shibuya Kimiyuki

About Shibuya Kimiyuki

(Tokyo New Drug Research Laboratories, Pharmaceutical Division, Kowa Co., Ltd., Tokyo, Japan)

About Tokyo New Drug Research Laboratories, Pharmaceutical Division, Kowa Co., Ltd., Tokyo, Japan

, 
Morikawa Shigeru

About Morikawa Shigeru

(Tokyo New Drug Research Laboratories, Pharmaceutical Division, Kowa Co., Ltd., Tokyo, Japan)

About Tokyo New Drug Research Laboratories, Pharmaceutical Division, Kowa Co., Ltd., Tokyo, Japan

, 
Miyamoto Masayoshi

About Miyamoto Masayoshi

(Tokyo New Drug Research Laboratories, Pharmaceutical Division, Kowa Co., Ltd., Tokyo, Japan)

About Tokyo New Drug Research Laboratories, Pharmaceutical Division, Kowa Co., Ltd., Tokyo, Japan

, 
Ogawa Shin-ichiro

About Ogawa Shin-ichiro

(Tokyo New Drug Research Laboratories, Pharmaceutical Division, Kowa Co., Ltd., Tokyo, Japan)

About Tokyo New Drug Research Laboratories, Pharmaceutical Division, Kowa Co., Ltd., Tokyo, Japan

, 
Tsunenari Yoshihiko

About Tsunenari Yoshihiko

(Tokyo New Drug Research Laboratories, Pharmaceutical Division, Kowa Co., Ltd., Tokyo, Japan)

About Tokyo New Drug Research Laboratories, Pharmaceutical Division, Kowa Co., Ltd., Tokyo, Japan

, 
Urano Yasuomi

About Urano Yasuomi

(Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University, Kyoto, Japan)

About Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University, Kyoto, Japan

, 
Noguchi Noriko

About Noguchi Noriko

(Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University, Kyoto, Japan)

About Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University, Kyoto, Japan


Material：
ACS Omega

About ACS Omega


Volume： 4  Issue： 16  Page： 16943-16955  Publication year： 2019 
JST Material Number： W5044A  ISSN： 2470-1343  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)
Abstract/Point：
Abstract/Point
Japanese summary of the article(about several hundred characters).
All summary is available on JDreamIII(charged).
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An acyl-CoA:cholesterol O-acyl...
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Thesaurus term：
Thesaurus term/Semi thesaurus term
Keywords indexed to the article.
All keywords is available on JDreamIII(charged).
On J-GLOBAL, this item will be available after more than half a year after the record posted. In addtion, medical articles require to login to MyJ-GLOBAL.
glioblastoma

About glioblastoma

, 
oral administration

About oral administration

, 
*hydroxy acid

About hydroxy acid

, 
Alzheimer disease

About Alzheimer disease

, 
*acyltransferase

About acyltransferase

, 
intranasal administration

About intranasal administration

, 
mouse(animal)

About mouse(animal)

, 
human(primates)

About human(primates)

, 
therapy

About therapy

, 
solubility(ratio)

About solubility(ratio)

, 
blood-brain barrier

About blood-brain barrier

, 
cholesterol ester

About cholesterol ester


Semi thesaurus term：
Thesaurus term/Semi thesaurus term
Keywords indexed to the article.
All keywords is available on JDreamIII(charged).
On J-GLOBAL, this item will be available after more than half a year after the record posted. In addtion, medical articles require to login to MyJ-GLOBAL.
過剰発現

About 過剰発現

, 
脳組織

About 脳組織

, 
鼻腔内

About 鼻腔内

, 
*阻害剤

About 阻害剤

, 【Automatic Indexing@JST】
JST classification (3)：
JST classification
Category name(code) classified by JST.
Basic biopharmacy 
(GY01021U)

About Basic biopharmacy

,  Basic research of diagnostic drugs 
(GW20010P)

About Basic research of diagnostic drugs

,  Medical materials 
(GA05040H)

About Medical materials

Terms in the title (9)：
Terms in the title
Keywords automatically extracted from the title.
ヒドロキシカルボン酸

About ヒドロキシカルボン酸

, 
溶液

About 溶液

, 
鼻

About 鼻

, 
経路

About 経路

, 
アシル-CoA

About アシル-CoA

, 
コレステロール

About コレステロール

, 
アシルトランスフェラーゼ

About アシルトランスフェラーゼ

, 
阻害剤

About 阻害剤

, 
脳標的化

About 脳標的化


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