Art

J-GLOBAL ID：201902272727056636   Reference number：19A0418742

DPP4 Inhibition Ameliorates Cardiac Function by Blocking the Cleavage of HMGB1 in Diabetic Mice After Myocardial Infarction

DPP4阻害は心筋梗塞後の糖尿病マウスにおいてHMGB1の切断を遮断することにより心機能を改善する

Author (12)： SATO Akihiko (Fukushima Medical Univ., Fukushima) ,  SUZUKI Satoshi (Fukushima Medical Univ., Fukushima) ,  WATANABE Shunsuke (Fukushima Medical Univ., Fukushima) ,  SHIMIZU Takeshi (Fukushima Medical Univ., Fukushima) ,  NAKAMURA Yuichi (Fukushima Medical Univ., Fukushima) ,  MISAKA Tomofumi (Fukushima Medical Univ., Fukushima) ,  YOKOKAWA Tetsuro (Fukushima Medical Univ., Fukushima) ,  SHISHIDO Tetsuro (Yamagata Univ. School of Medicine, Yamagata, JPN) ,  SAITOH Shu-ichi (Fukushima Medical Univ., Fukushima) ,  ISHIDA Takafumi (Fukushima Medical Univ., Fukushima) ,  KUBOTA Isao (Yamagata Univ. School of Medicine, Yamagata, JPN) ,  TAKEISHI Yasuchika (Fukushima Medical Univ., Fukushima)
Material： International Heart Journal  (Int Heart J)
Volume： 58  Issue： 5  Page： 778-786(J-STAGE)  Publication year： 2017 
JST Material Number： Z0752A  ISSN： 1349-2365  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： mouse(animal) ,...
Semi thesaurus term： *DPP-IV inhibitor ,...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=19A0418742&from=J-GLOBAL&jstjournalNo=Z0752A") }}

JST classification (2)： Basic research of cardioactive drugs  (GW07020N) ,  Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W)

Substance index (1)： Anagliptin

Reference (45)：

• 1. Roger VL, Go AS, Lloyd-Jones DM, et al. Heart disease and stroke statistics-2012 update: a report from the American Heart Association. Circulation 2012; 125: e2-e220.
• 2. Miura T, Miki T. Limitation of myocardial infarct size in the clinical setting: current status and challenges in translating animal experiments into clinical therapy. Basic Res Cardiol 2008; 103: 501-13. (Review)
• 3. Hausenloy DJ, Yellon DM. Targeting myocardial reperfusion injury-The Search Continues. N Engl J Med 2015; 373: 1073-5.
• 4. Heusch G. Molecular basis of cardioprotection: signal transduction in ischemic pre-, post-, and remote conditioning. Circ Res 2015; 116: 674-99. (Review)
• 5. Thomas JO, Stott K. H1 and HMGB1: modulators of chromatin structure. Biochem Soc Trans 2012; 40: 341-6. (Review)

Terms in the title (7)： DPP4 ,  阻害 ,  心筋梗塞 ,  糖尿病マウス ,  HMGB1 ,  遮断 ,  心機能