Art

J-GLOBAL ID：201902272828643266   Reference number：19A0790813

Progranulin reduces insoluble TDP-43 levels, slows down axonal degeneration and prolongs survival in mutant TDP-43 mice

プログランリンは変異TDP-43マウスにおいて不溶性TDP-43レベルを低下させ,軸索変性を遅延させ,生存を延長する【JST・京大機械翻訳】

Author (17)： Beel Sander (Department of Neurosciences, Experimental Neurology and Leuven Brain Institute (LBI), KU Leuven - University of Leuven, Leuven, Belgium) ,  Beel Sander (VIB, Center for Brain & Disease Research, Laboratory of Neurobiology, Leuven, Belgium) ,  Herdewyn Sarah (Department of Neurosciences, Experimental Neurology and Leuven Brain Institute (LBI), KU Leuven - University of Leuven, Leuven, Belgium) ,  Herdewyn Sarah (VIB, Center for Brain & Disease Research, Laboratory of Neurobiology, Leuven, Belgium) ,  Fazal Raheem (Department of Neurosciences, Experimental Neurology and Leuven Brain Institute (LBI), KU Leuven - University of Leuven, Leuven, Belgium) ,  Fazal Raheem (VIB, Center for Brain & Disease Research, Laboratory of Neurobiology, Leuven, Belgium) ,  Decker Mathias De (Department of Neurosciences, Experimental Neurology and Leuven Brain Institute (LBI), KU Leuven - University of Leuven, Leuven, Belgium) ,  Decker Mathias De (VIB, Center for Brain & Disease Research, Laboratory of Neurobiology, Leuven, Belgium) ,  Moisse Matthieu (Department of Neurosciences, Experimental Neurology and Leuven Brain Institute (LBI), KU Leuven - University of Leuven, Leuven, Belgium) ,  Moisse Matthieu (VIB, Center for Brain & Disease Research, Laboratory of Neurobiology, Leuven, Belgium) ,  Robberecht Wim (Department of Neurosciences, Experimental Neurology and Leuven Brain Institute (LBI), KU Leuven - University of Leuven, Leuven, Belgium) ,  Robberecht Wim (Department of Neurology, University Hospital Leuven, Leuven, Belgium) ,  Bosch Ludo Van Den (Department of Neurosciences, Experimental Neurology and Leuven Brain Institute (LBI), KU Leuven - University of Leuven, Leuven, Belgium) ,  Bosch Ludo Van Den (VIB, Center for Brain & Disease Research, Laboratory of Neurobiology, Leuven, Belgium) ,  Damme Philip Van (Department of Neurosciences, Experimental Neurology and Leuven Brain Institute (LBI), KU Leuven - University of Leuven, Leuven, Belgium) ,  Damme Philip Van (VIB, Center for Brain & Disease Research, Laboratory of Neurobiology, Leuven, Belgium) ,  Damme Philip Van (Department of Neurology, University Hospital Leuven, Leuven, Belgium)
Material： Molecular Neurodegeneration (Web)
Volume： 13  Issue： 1  Page： 55  Publication year： 2018 
JST Material Number： U7339A  ISSN： 1750-1326  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： TAR DNA binding protein 43 (TD...

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Thesaurus term： Heredity ,  pathological state ,  missense mutation ,  human ,  DNA binding protein ,  *axon ,  Amyotrophic Lateral Sclerosis ,  Dementia ,  protective action ,  gene ,  Phenotype ,  Spinal Cord ,  overexpression ,  Progranulin ,  *TDP-43
Semi thesaurus term： 神経変性 , 【Automatic Indexing@JST】

Author keywords (4)： Frontotemporal dementia ,  Amyotrophic lateral sclerosis ,  TDP-43 ,  Progranulin

JST classification (2)： Basic neurology  (GN01020W) ,  Gene expression  (EC02040Q)

Reference (57)：

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Terms in the title (7)： 変異 ,  TDP-43 ,  マウス ,  不溶性 ,  軸索変性 ,  遅延 ,  生存