Art

J-GLOBAL ID：201902274043346982   Reference number：19A0253729

Expression and Functional Characterization of Drug Transporters in Brain Microvascular Endothelial Cells Derived from Human Induced Pluripotent Stem Cells

ヒト人工多能性幹細胞由来の脳微小血管内皮細胞における薬物輸送体の発現と機能的特性化【JST・京大機械翻訳】

Author (9)： Kurosawa Toshiki (Laboratory of Drug Disposition & Pharmacokinetics, Faculty of Pharma-Sciences, Teikyo University) ,  Tega Yuma (Laboratory of Drug Disposition & Pharmacokinetics, Faculty of Pharma-Sciences, Teikyo University) ,  Higuchi Kei (Laboratory of Drug Disposition & Pharmacokinetics, Faculty of Pharma-Sciences, Teikyo University) ,  Yamaguchi Tomoko (Laboratory of Stem Cell Regulation, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan) ,  Nakakura Takashi (Department of Anatomy and Cell Biology, School of Medicine, Teikyo University) ,  Mochizuki Tatsuki (Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan) ,  Kusuhara Hiroyuki (Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan) ,  Kawabata Kenji (Laboratory of Stem Cell Regulation, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan) ,  Deguchi Yoshiharu (Laboratory of Drug Disposition & Pharmacokinetics, Faculty of Pharma-Sciences, Teikyo University)
Material： Molecular Pharmaceutics
Volume： 15  Issue： 12  Page： 5546-5555  Publication year： 2018 
JST Material Number： W3686A  ISSN： 1543-8384  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Brain microvascular endothelia...

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Thesaurus term： Blood-Brain Barrier ,  *characterization ,  asymmetry ,  substrate (biochemistry) ,  gene expression ,  *human ,  proton ,  nutrient ,  mRNA ,  MCT1 ,  Transcytosis ,  Fermi Gamma-ray Space Telescope ,  Cardiovascular System ,  molecular genetic phenomenon ,  nitrogen heterocyclic compound ,  oxygen heterocyclic compound ,  carboxamide ,  phenol ether ,  polynuclear aromatic compound
Semi thesaurus term： 阻害剤 ,  GLAST ,  *輸送体 , 【Automatic Indexing@JST】

Author keywords (5)： human iPS cell ,  blood-brain barrier ,  gene expression ,  tight junction ,  transporter

JST classification (3)： Transport of cell membrane  (EF04020R) ,  Basic medicine on cardiovascular system  (GJ01020K) ,  Cell physiology in general  (EF02010S)

Substance index (1)： Prazosin

Terms in the title (7)： ヒト ,  人工多能性幹細胞 ,  脳 ,  微小血管内皮細胞 ,  薬物輸送体 ,  発現 ,  特性化