Art

J-GLOBAL ID：201902275467640780   Reference number：19A2287663

CTLA4-Ig Directly Inhibits Osteoclastogenesis by Interfering With Intracellular Calcium Oscillations in Bone Marrow Macrophages

CTLA4-Igは骨髄マクロファージにおける細胞内カルシウム振動との干渉により破骨細胞形成を直接阻害する【JST・京大機械翻訳】

Author (24)： Okada Hiroyuki (Department of Orthopaedic Surgery, The University of Tokyo, Tokyo, Japan) ,  Kajiya Hiroshi (Department of Physiological Science and Molecular Biology, Fukuoka Dental College, Fukuoka, Japan) ,  Omata Yasunori (Department of Orthopaedic Surgery, The University of Tokyo, Tokyo, Japan) ,  Matsumoto Takumi (Department of Orthopaedic Surgery, The University of Tokyo, Tokyo, Japan) ,  Sato Yuiko (Department of Orthopedic Surgery, Keio University School of Medicine, Tokyo, Japan) ,  Kobayashi Tami (Department of Orthopedic Surgery, Keio University School of Medicine, Tokyo, Japan) ,  Nakamura Satoshi (Department of Orthopedic Surgery, Keio University School of Medicine, Tokyo, Japan) ,  Kaneko Yosuke (Department of Orthopedic Surgery, Keio University School of Medicine, Tokyo, Japan) ,  Nakamura Shinya (Department of Orthopaedic Surgery, The University of Tokyo, Tokyo, Japan) ,  Koyama Takuma (Department of Orthopaedic Surgery, The University of Tokyo, Tokyo, Japan) ,  Sudo Shunichi (Department of Physiological Science and Molecular Biology, Fukuoka Dental College, Fukuoka, Japan) ,  Shin Masashi (Department of Physiological Science and Molecular Biology, Fukuoka Dental College, Fukuoka, Japan) ,  Okamoto Fujio (Department of Physiological Science and Molecular Biology, Fukuoka Dental College, Fukuoka, Japan) ,  Watanabe Hisato (Department of Orthopaedic Surgery, The University of Tokyo, Tokyo, Japan) ,  Tachibana Naohiro (Department of Orthopaedic Surgery, The University of Tokyo, Tokyo, Japan) ,  Hirose Jun (Department of Orthopaedic Surgery, The University of Tokyo, Tokyo, Japan) ,  Saito Taku (Department of Orthopaedic Surgery, The University of Tokyo, Tokyo, Japan) ,  Takai Toshiyuki (Department of Experimental Immunology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Fukuoka, Japan) ,  Matsumoto Morio (Department of Orthopedic Surgery, Keio University School of Medicine, Tokyo, Japan) ,  Nakamura Masaya (Department of Orthopedic Surgery, Keio University School of Medicine, Tokyo, Japan) ,  Okabe Koji (Department of Physiological Science and Molecular Biology, Fukuoka Dental College, Fukuoka, Japan) ,  Miyamoto Takeshi (Department of Orthopedic Surgery, Keio University School of Medicine, Tokyo, Japan) ,  Miyamoto Takeshi (Department of Orthopaedic Surgery, Kumamoto University, Kumamoto, Japan) ,  Tanaka Sakae (Department of Orthopaedic Surgery, The University of Tokyo, Tokyo, Japan)
Material： Journal of Bone and Mineral Research  (JBMR)
Volume： 34  Issue： 9  Page： 1744-1752  Publication year： 2019 
JST Material Number： W1633A  ISSN： 0884-0431  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： CTLA4-Ig (cytotoxic T-lymphocy...

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Thesaurus term： immunoglobulin ,  in vitro experiment ,  human(primates) ,  complex(substance) ,  therapy ,  *mouse(animal) ,  bone resorption ,  RANKL ,  administration(biology) ,  antigen ,  down-regulation ,  rheumatoid arthritis
Semi thesaurus term： *カルシウム波 ,  アバタセプト ,  *破骨細胞形成 ,  *CTLA-4抗原 , 【Automatic Indexing@JST】

Author keywords (4)： CTLA4 ,  ABATACEPT ,  OSTEOCLAST DIFFERENTIATION ,  CALCIUM OSCILLATION

JST classification (4)： Cell physiology in general  (EF02010S) ,  Biological function  (EB03040U) ,  Basic medicine on musculoskeletal system  (GG01020B) ,  Skeletal system  (EJ10030R)

Terms in the title (6)： CTLA4 ,  骨髄マクロファージ ,  細胞内カルシウム ,  干渉 ,  破骨細胞形成 ,  阻害