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J-GLOBAL ID：201902276255957026   Reference number：19A1492593

BRCA1 ensures genome integrity by eliminating estrogen-induced pathological topoisomerase II-DNA complexes

BRCA1はエストロゲン誘発性の病理学的トポイソメラーゼII-DNA複合体を除去することによりゲノムの完全性を保証する【JST・京大機械翻訳】

Author (18)： Sasanuma Hiroyuki (Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, 606-8501 Kyoto, Japan) ,  Tsuda Masataka (Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, 606-8501 Kyoto, Japan) ,  Tsuda Masataka (Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University, 739-8526 Higashi-Hiroshima, Japan) ,  Morimoto Suguru (Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, 606-8501 Kyoto, Japan) ,  Saha Liton Kumar (Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, 606-8501 Kyoto, Japan) ,  Rahman Md Maminur (Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, 606-8501 Kyoto, Japan) ,  Kiyooka Yusuke (Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, 606-8501 Kyoto, Japan) ,  Fujiike Haruna (Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, 606-8501 Kyoto, Japan) ,  Cherniack Andrew D. (The Eli and Edythe L. Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142) ,  Itou Junji (Department of Breast Surgery, Graduate School of Medicine, Kyoto University, 606-8507 Kyoto, Japan) ,  Callen Moreu Elsa (Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD 20892) ,  Toi Masakazu (Department of Breast Surgery, Graduate School of Medicine, Kyoto University, 606-8507 Kyoto, Japan) ,  Nakada Shinichiro (Department of Bioregulation and Cellular Response, Graduate School of Medicine, Osaka University, Suita, 565-0871 Osaka, Japan) ,  Tanaka Hisashi (Department of Surgery, Cedars-Sinai Medical Center, West Hollywood, CA 90048) ,  Tsutsui Ken (Department of Neurogenomics, Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama University, 700-8558 Okayama, Japan) ,  Yamada Shintaro (Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, 606-8501 Kyoto, Japan) ,  Nussenzweig Andre (Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD 20892) ,  Takeda Shunichi (Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, 606-8501 Kyoto, Japan)
Material： Proceedings of the National Academy of Sciences of the United States of America  (PNAS)
Volume： 115  Issue： 45  Page： E10642-E10651  Publication year： 2018 
JST Material Number： D0387A  ISSN： 0027-8424  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Women having BRCA1 germ-line m...

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Thesaurus term： in vitro experiment ,  Mus musculus ,  BRCA1 gene ,  breast tumor ,  endonuclease ,  *DNA ,  Cell Cycle ,  monophase ,  *pathological state ,  human ,  Breast ,  epithelial cell ,  *complex (substance) ,  non-homologous end joining ,  *BRCA1 Protein ,  Myomorpha ,  alicyclic compound ,  lactone ,  enzyme inhibitor ,  phenolic compound ,  glycoside (except carbohydrate) ,  olefin compound ,  pyranoside ,  glucoside ,  phenol ether ,  polynuclear aromatic compound

Author keywords (5)： BRCA1 ,  estradiol (E2) ,  topoisomerase II ,  HBOC syndrome ,  breast cancer

JST classification (3)： Carcinogenic mechanisms and factors  (GE02020C) ,  Molecular genetics in general  (EC02010J) ,  Gene expression  (EC02040Q)

Substance index (1)： Etoposide

Terms in the title (8)： BRCA1 ,  エストロゲン ,  病理学 ,  トポイソメラーゼII ,  DNA複合体 ,  ゲノム ,  完全性 ,  保証