Art

J-GLOBAL ID：201902276582394382   Reference number：19A2328167

Age-related changes in DNA methylation levels at CpG sites in bull spermatozoa and in vitro fertilization-derived blastocyst-stage embryos revealed by combined bisulfite restriction analysis

複合亜硫酸水素制限分析により明らかにされたウシ精子およびin vitro受精由来胚盤胞期胚におけるCpG部位でのDNAメチル化レベルの年齢関連変化

Author (11)： TAKEDA Kumiko (Institute of Livestock and Grassland Science, NARO, Ibaraki 305-0901, Japan) ,  KOBAYASHI Eiji (Institute of Livestock and Grassland Science, NARO, Ibaraki 305-0901, Japan) ,  NISHINO Kagetomo (Beef Cattle Institute, Ibaraki Prefectural Livestock Research Center, Ibaraki 319-2224, Japan) ,  IMAI Akira (Hiroshima Prefectural Livestock Technology Research Center, Hiroshima 739-0151, Japan) ,  ADACHI Hiromichi (Hida Beef Cattle Research, Gifu Prefectural Livestock Research Institute, Gifu 506-0101, Japan) ,  HOSHINO Yoichiro (Hida Beef Cattle Research, Gifu Prefectural Livestock Research Institute, Gifu 506-0101, Japan) ,  HOSHINO Yoichiro (Kyoto University, Kyoto 622-0203, Japan) ,  IWAO Ken (Tottori Prefectural Livestock Research Institute, Tottori 689-2503, Japan) ,  AKAGI Satoshi (Institute of Livestock and Grassland Science, NARO, Ibaraki 305-0901, Japan) ,  KANEDA Masahiro (Tokyo University of Agriculture and Technology, Tokyo 183-8509, Japan) ,  WATANABE Shinya (Institute of Livestock and Grassland Science, NARO, Ibaraki 305-0901, Japan)
Material： Journal of Reproduction and Development  (J Reprod Dev)
Volume： 65  Issue： 4  Page： 305-312(J-STAGE)  Publication year： 2019 
JST Material Number： F0766A  ISSN： 0916-8818  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *cattle ,...

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Author keywords (5)： Age-related changes ,  Bull spermatozoa ,  Combined bisulfite restriction analysis (COBRA) ,  DNA methylation ,  In vitro fertilization (IVF) embryos

JST classification (2)： Cattle  (FD02020Y) ,  Reproductive(=genital)organs  (EJ15020P)

Reference (27)：

• 1. Rahman MB, Schellander K, Luceño NL, Van Soom A. Heat stress responses in spermatozoa: Mechanisms and consequences for cattle fertility. Theriogenology 2018; 113: 102-112.
• 2. Tunc O, Tremellen K. Oxidative DNA damage impairs global sperm DNA methylation in infertile men. J Assist Reprod Genet 2009; 26: 537-544.
• 3. Aston KI, Uren PJ, Jenkins TG, Horsager A, Cairns BR, Smith AD, Carrell DT. Aberrant sperm DNA methylation predicts male fertility status and embryo quality. Fertil Steril 2015; 104: 1388-1397.e1-5.
• 4. Jenkins TG, Carrell DT. Dynamic alterations in the paternal epigenetic landscape following fertilization. Front Genet 2012; 3: 143.
• 5. Carrell DT. Epigenetics of the male gamete. Fertil Steril 2012; 97: 267-274.

Terms in the title (12)： 亜硫酸 ,  水素 ,  制限 ,  分析 ,  ウシ ,  精子 ,  受精 ,  胚盤胞 ,  胚 ,  CPG ,  DNAメチル化 ,  年齢