Art

J-GLOBAL ID：201902278537265292   Reference number：19A1569748

Notchシグナル阻害作用を有する光学活性スピロオキシインドール誘導体の創成研究

Author (8)： ARAI MIDORI (千葉大 大学院) ,  ARAI MIDORI (千葉大 ソフト分子活性化研究セ) ,  KAWANO HARUKA (千葉大 大学院) ,  ARAI TAKAYOSHI (千葉大 大学院) ,  ARAI TAKAYOSHI (千葉大 ソフト分子活性化研究セ) ,  ARAI TAKAYOSHI (千葉ヨウ素資源イノベーションセ) ,  ISHIBASHI MASAMI (千葉大 大学院) ,  ISHIBASHI MASAMI (千葉大 ソフト分子活性化研究セ)
Material： シンポジウム「モレキュラー・キラリティー」講演要旨集  (シンポジウム モレキュラー・キラリティー要旨集)
Volume： 2019  Page： 136-137  Publication year： Jun. 11, 2019 
JST Material Number： L2525A  ISSN： 1881-0861  Document type： Proceedings
Article type： 短報  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： drug ,  *hydroxy compound ,  *nitrogen heterocyclic compound ,  *polynuclear aromatic compound ,  *cycloaddition ,  nickel catalyst ,  nickel complex ,  catalytic reaction ,  asymmetric reaction ,  bioassay ,  optical activity ,  toxicity test ,  concentration (ratio) ,  Structure-Activity Relationship ,  asymmetric catalysis ,  compound library ,  luciferase assay ,  Signal Transduction ,  Notch signaling ,  *Oxindoles ,  50% inhibitory concentration
Semi thesaurus term： cellular signal transduction ,  Notch signalling ,  notchシグナル阻害剤 ,  inhibitor ,  *oxindol derivative ,  IC50

JST classification (2)： Condensed derivatives of pyrroles  (CF07077C) ,  Cyclization reaction,ring-opening reaction  (CF02050I)

Substance index (30)： tert-Butyl (2'S,3S,4'S,5'S)-4'-(furan-2-yl)-2-oxo-2'-(thiophen-2-yl)-1H-spiro[indole-3,3'-pyrrolidine]-5'-carboxylate ,  tert-butyl (2'S,3S,4'S,5'S)-4'-(furan-2-yl)-2'-(5-iodothiophen-2-yl)-2-oxo-1H-spiro[indole-3,3'-pyrrolidine]-5'-carboxylate ,  tert-butyl (2'S,3S,4'S,5'S)-4'-(furan-2-yl)-2-oxo-2'-(pyridin-2-yl)-1H-spiro[indole-3,3'-pyrrolidine]-5'-carboxylate ,  (3S)-2α-Phenyl-4α-(2-furanyl)-2′-oxospiro[pyrrolidine-3,3′(2′H)-[1H]indole]-5β-carboxylic acid tert-butyl ester ,  tert-butyl (2'R,3S,4'S,5'S)-4'-(furan-2-yl)-2'-(1H-indol-5-yl)-2-oxo-1H-spiro[indole-3,3'-pyrrolidine]-5'-carboxylate ,  tert-butyl (2'S,3S,4'S,5'S)-4'-(5-bromofuran-2-yl)-2'-(5-bromothiophen-2-yl)-2-oxo-1H-spiro[indole-3,3'-pyrrolidine]-5'-carboxylate ,  tert-butyl (2'S,3S,4'S,5'S)-4'-(5-bromofuran-2-yl)-2-oxo-2'-(1H-pyrrol-2-yl)-1H-spiro[indole-3,3'-pyrrolidine]-5'-carboxylate ,  tert-butyl (2'R,3S,4'S,5'S)-4'-(5-bromofuran-2-yl)-2-oxo-2'-phenyl-1H-spiro[indole-3,3'-pyrrolidine]-5'-carboxylate ,  tert-butyl (2'R,3S,4'S,5'S)-4'-(5-bromofuran-2-yl)-2'-(1H-indol-5-yl)-2-oxo-1H-spiro[indole-3,3'-pyrrolidine]-5'-carboxylate ,  tert-butyl (2'S,3S,4'S,5'S)-4'-(5-iodofuran-2-yl)-2'-(5-iodothiophen-2-yl)-2-oxo-1H-spiro[indole-3,3'-pyrrolidine]-5'-carboxylate ,  tert-butyl (2'S,3S,4'S,5'S)-4'-(5-iodofuran-2-yl)-2-oxo-2'-(pyridin-2-yl)-1H-spiro[indole-3,3'-pyrrolidine]-5'-carboxylate ,  tert-butyl (2'R,3S,4'S,5'S)-4'-(5-iodofuran-2-yl)-2-oxo-2'-phenyl-1H-spiro[indole-3,3'-pyrrolidine]-5'-carboxylate ,  tert-butyl (2'R,3S,4'S,5'S)-2'-(1H-indol-5-yl)-4'-(5-iodofuran-2-yl)-2-oxo-1H-spiro[indole-3,3'-pyrrolidine]-5'-carboxylate ,  tert-butyl (2'S,3S,4'S,5'S)-2'-(5-bromothiophen-2-yl)-2-oxo-4'-(thiophen-2-yl)-1H-spiro[indole-3,3'-pyrrolidine]-5'-carboxylate ,  tert-butyl (2'S,3S,4'S,5'S)-2-oxo-2'-(1H-pyrrol-2-yl)-4'-(thiophen-2-yl)-1H-spiro[indole-3,3'-pyrrolidine]-5'-carboxylate ,  tert-butyl (2'R,3S,4'S,5'S)-2-oxo-2'-phenyl-4'-(thiophen-2-yl)-1H-spiro[indole-3,3'-pyrrolidine]-5'-carboxylate ,  tert-butyl (2'R,3S,4'S,5'S)-2'-(1H-indol-5-yl)-2-oxo-4'-(thiophen-2-yl)-1H-spiro[indole-3,3'-pyrrolidine]-5'-carboxylate ,  tert-butyl (2'S,3S,4'S,5'S)-4'-(5-bromothiophen-2-yl)-2'-(5-iodothiophen-2-yl)-2-oxo-1H-spiro[indole-3,3'-pyrrolidine]-5'-carboxylate ,  tert-butyl (2'S,3S,4'S,5'S)-4'-(5-bromothiophen-2-yl)-2-oxo-2'-(pyridin-2-yl)-1H-spiro[indole-3,3'-pyrrolidine]-5'-carboxylate ,  tert-butyl (2'R,3S,4'S,5'S)-4'-(5-bromothiophen-2-yl)-2-oxo-2'-phenyl-1H-spiro[indole-3,3'-pyrrolidine]-5'-carboxylate ,  tert-butyl (2'R,3S,4'S,5'S)-4'-(5-bromothiophen-2-yl)-2'-(1H-indol-5-yl)-2-oxo-1H-spiro[indole-3,3'-pyrrolidine]-5'-carboxylate ,  tert-butyl (2'S,3S,4'S,5'S)-4'-(5-iodothiophen-2-yl)-2-oxo-2'-(thiophen-2-yl)-1H-spiro[indole-3,3'-pyrrolidine]-5'-carboxylate ,  tert-butyl (2'S,3S,4'S,5'S)-4'-(5-iodothiophen-2-yl)-2-oxo-2'-(1H-pyrrol-2-yl)-1H-spiro[indole-3,3'-pyrrolidine]-5'-carboxylate ,  tert-butyl (2'R,3S,4'S,5'S)-4'-(5-iodothiophen-2-yl)-2-oxo-2'-phenyl-1H-spiro[indole-3,3'-pyrrolidine]-5'-carboxylate ,  tert-butyl (2'R,3S,4'S,5'S)-2'-(1H-indol-5-yl)-4'-(5-iodothiophen-2-yl)-2-oxo-1H-spiro[indole-3,3'-pyrrolidine]-5'-carboxylate ,  tert-butyl (2'S,3S,4'S,5'S)-2'-(5-bromothiophen-2-yl)-2-oxo-4'-phenyl-1H-spiro[indole-3,3'-pyrrolidine]-5'-carboxylate ,  (2′S,3S,4′S,5′S)-2′-(Pyridine-2-yl)-2-oxo-4′-phenylspiro[1H-indole-3(2H),3′-pyrrolidine]-5′-carboxylic acid tert-butyl ester ,  tert-butyl (2'R,3S,4'S,5'S)-2'-(1H-indol-5-yl)-2-oxo-4'-phenyl-1H-spiro[indole-3,3'-pyrrolidine]-5'-carboxylate ,  (2′S,3S,4′S,5′S)-2′-(1H-Pyrrole-2-yl)-2-oxo-4′-phenylspiro[1H-indole-3(2H),3′-pyrrolidine]-5′-carboxylic acid tert-butyl ester ,  tert-butyl (2'S,3S,4'S,5'S)-2'-(5-bromofuran-2-yl)-2-oxo-4'-phenyl-1H-spiro[indole-3,3'-pyrrolidine]-5'-carboxylate

Terms in the title (7)： Notchシグナル ,  阻害作用 ,  光学活性 ,  スピロオキシインドール ,  誘導体 ,  創成 ,  研究