Art

J-GLOBAL ID：201902279686646991   Reference number：19A1181668

Pressure overload inhibits glucocorticoid receptor transcriptional activity in cardiomyocytes and promotes pathological cardiac hypertrophy

圧過負荷は心筋細胞におけるグルココルチコイド受容体転写活性を阻害し,病理学的心臓肥大を促進する【JST・京大機械翻訳】

Author (13)： Matsuhashi Tomohiro (Department of Cardiology, Keio University School of Medicine, Tokyo, Japan) ,  Endo Jin (Department of Cardiology, Keio University School of Medicine, Tokyo, Japan) ,  Katsumata Yoshinori (Department of Cardiology, Keio University School of Medicine, Tokyo, Japan) ,  Yamamoto Tsunehisa (Department of Cardiology, Keio University School of Medicine, Tokyo, Japan) ,  Shimizu Noriaki (Division of Rheumatology, Center for Antibody and Vaccine Therapy, IMSUT Hospital, Institute of Medical Science University of Tokyo, Tokyo, Japan) ,  Yoshikawa Noritada (Division of Rheumatology, Center for Antibody and Vaccine Therapy, IMSUT Hospital, Institute of Medical Science University of Tokyo, Tokyo, Japan) ,  Kataoka Masaharu (Department of Cardiology, Keio University School of Medicine, Tokyo, Japan) ,  Isobe Sarasa (Department of Cardiology, Keio University School of Medicine, Tokyo, Japan) ,  Moriyama Hidenori (Department of Cardiology, Keio University School of Medicine, Tokyo, Japan) ,  Goto Shinichi (Department of Cardiology, Keio University School of Medicine, Tokyo, Japan) ,  Fukuda Keiichi (Department of Cardiology, Keio University School of Medicine, Tokyo, Japan) ,  Tanaka Hirotoshi (Division of Rheumatology, Center for Antibody and Vaccine Therapy, IMSUT Hospital, Institute of Medical Science University of Tokyo, Tokyo, Japan) ,  Sano Motoaki (Department of Cardiology, Keio University School of Medicine, Tokyo, Japan)
Material： Journal of Molecular and Cellular Cardiology  (J Mol Cell Cardiol)
Volume： 130  Page： 122-130  Publication year： 2019 
JST Material Number： E0538A  ISSN： 0022-2828  CODEN： JMCDAY  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Glucocorticoid receptor (GR) i...

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Thesaurus term： plasma(blood) ,  gene expression ,  therapeutic planning ,  fetus ,  *cardiac hypertrophy ,  *overload ,  *cardiac myocyte ,  *heart ,  cardiac insufficiency ,  promoter(genetics) ,  mouse(animal) ,  steroid ,  enone ,  alicyclic alcohol ,  alicyclic ketone ,  diol ,  diketone ,  secondary alcohol ,  hydroxy ketone
Semi thesaurus term： 標的遺伝子 ,  心臓リモデリング ,  圧負荷 , 【Automatic Indexing@JST】

Author keywords (6)： Glucocorticoid receptor ,  KLF15 ,  mTORC1 ,  Mineral corticoid receptor ,  Cardiac hypertrophy ,  Heart failure

JST classification (1)： Basic medicine on cardiovascular system  (GJ01020K)

Substance index (1)： Corticosterone

Terms in the title (9)： 圧 ,  過負荷 ,  心筋細胞 ,  グルココルチコイド受容体 ,  転写活性 ,  阻害 ,  病理学 ,  心臓肥大 ,  促進