Art

J-GLOBAL ID：201902286780180262   Reference number：19A2679909

Network-guided analysis of hippocampal proteome identifies novel proteins that colocalize with Aβ in a mice model of early-stage Alzheimer’s disease

海馬プロテオームのネットワーク誘導解析は初期段階Alzheimer病のマウスモデルにおいてAβと共局在する新規蛋白質を同定する【JST・京大機械翻訳】

Author (18)： Aladeokin Aderemi Caleb (Department of Molecular Pharmacology & Neurobiology, Yokohama City University, 236-0004, Japan) ,  Akiyama Tomoko (Advanced Medical Research Center, Yokohama City University, 236-0004, Japan) ,  Kimura Ayuko (Advanced Medical Research Center, Yokohama City University, 236-0004, Japan) ,  Kimura Yayoi (Advanced Medical Research Center, Yokohama City University, 236-0004, Japan) ,  Takahashi-Jitsuki Aoi (Department of Molecular Pharmacology & Neurobiology, Yokohama City University, 236-0004, Japan) ,  Takahashi-Jitsuki Aoi (Department of Physiology, Yokohama City University, 236-0004, Japan) ,  Nakamura Haruko (Department of Neurology & Stroke Medicine, Yokohama City University, 236-0004, Japan) ,  Makihara Hiroko (Department of Molecular Pharmacology & Neurobiology, Yokohama City University, 236-0004, Japan) ,  Makihara Hiroko (Department of Biological Science & Nursing, Yokohama City University, 236-0004, Japan) ,  Masukawa Daiki (Department of Molecular Pharmacology & Neurobiology, Yokohama City University, 236-0004, Japan) ,  Nakabayashi Jun (Advanced Medical Research Center, Yokohama City University, 236-0004, Japan) ,  Hirano Hisashi (Advanced Medical Research Center, Yokohama City University, 236-0004, Japan) ,  Nakamura Fumio (Department of Molecular Pharmacology & Neurobiology, Yokohama City University, 236-0004, Japan) ,  Nakamura Fumio (Department of Biochemistry, Tokyo Women’s Medical University, Japan) ,  Saito Takashi (Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Wako, Japan) ,  Saito Takashi (Department of Neurocognitive Science, Nagoya City University Graduate School of Medical Science, 467-8601, Japan) ,  Saido Takaomi (Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Wako, Japan) ,  Goshima Yoshio (Department of Molecular Pharmacology & Neurobiology, Yokohama City University, 236-0004, Japan)
Material： Neurobiology of Disease  (Neurobiol Dis)
Volume： 132  Page： Null  Publication year： 2019 
JST Material Number： W1774A  ISSN： 0969-9961  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Alzheimer’s disease (AD) is an...

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Thesaurus term： *protein ,  mitochondria ,  *hippocampus ,  up-regulation ,  inflammation ,  *Alzheimer disease ,  *proteome ,  plaque ,  interaction ,  down-regulation ,  amyloid beta-protein ,  *mouse(animal) ,  biomarker ,  human(primates)
Semi thesaurus term： 過剰発現 ,  共局在化 , 【Automatic Indexing@JST】

Author keywords (6)： Alzheimer’s disease ,  Proteomics ,  Interactome ,  Protein-protein interaction networks ,  Early-stage ,  Amyloid beta

JST classification (3)： Basic neurology  (GN01020W) ,  Cell physiology in general  (EF02010S) ,  Nervous system diseases  (GN03000O)

Terms in the title (9)： 海馬 ,  プロテオーム ,  誘導 ,  解析 ,  初期段階 ,  Alzheimer病 ,  マウスモデル ,  蛋白質 ,  同定