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J-GLOBAL ID：201902287595610665   Reference number：19A1920761

Deletion of CD38 Suppresses Glial Activation and Neuroinflammation in a Mouse Model of Demyelination

CD38の欠失は脱髄のマウスモデルにおけるグリア活性化と神経炎症を抑制する【JST・京大機械翻訳】

Author (14)： Roboon Jureepon (Department of Neuroanatomy, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan) ,  Hattori Tsuyoshi (Department of Neuroanatomy, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan) ,  Ishii Hiroshi (Department of Neuroanatomy, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan) ,  Takarada-Iemata Mika (Department of Neuroanatomy, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan) ,  Le Thuong Manh (Department of Neuroanatomy, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan) ,  Shiraishi Yoshitake (Department of Functional Anatomy, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan) ,  Ozaki Noriyuki (Department of Functional Anatomy, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan) ,  Yamamoto Yasuhiko (Department of Biochemistry and Molecular Vascular Biology, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan) ,  Sugawara Akira (Department of Molecular Endocrinology, Tohoku University Graduate School of Medicine, Sendai, Japan) ,  Okamoto Hiroshi (Department of Biochemistry and Molecular Vascular Biology, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan) ,  Okamoto Hiroshi (Department of Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan) ,  Higashida Haruhiro (Research Center for Child Mental Development, Kanazawa University, Kanazawa, Japan) ,  Kitao Yasuko (Department of Neuroanatomy, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan) ,  Hori Osamu (Department of Neuroanatomy, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan)
Material： Frontiers in Cellular Neuroscience (Web)
Volume： 13  Page： 258  Publication year： 2019 
JST Material Number： U7064A  ISSN： 1662-5102  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： CD38 is an enzyme that catalyz...

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Thesaurus term： myelin ,  administration (biology) ,  Apoptosis ,  microglia ,  *CD38 antigen ,  astrocyte ,  oligodendroglia ,  wild type ,  *glia cell ,  enzyme ,  culture (biology)
Semi thesaurus term： リモデリング ,  神経変性 ,  *髄鞘脱落 , 【Automatic Indexing@JST】

Author keywords (5)： demyelination ,  gliosis ,  cuprizone ,  neuroinflammation ,  NAD⁺

JST classification (1)： Basic neurology  (GN01020W)

Substance index (1)： Cuprizone

Reference (48)：

• Akimoto N., Kamiyama Y., Yamafuji M., Fujita K., Seike T., Kido M., et al (2013). Immunohistochemistry of CD38 in different cell types in the hypothalamus and pituitary of male mice. Am. Sci. Pub. 2 54-61. doi: 10.1166/msr.2013.1021
• Blakemore W. F. (1972). Observations on oligodendrocyte degeneration, the resolution of status spongiosus and remyelination in cuprizone intoxication in mice. J. Neurocytol. 1 413-426. doi: 10.1007/bf01102943
• Bond L., Lusher D., Williams I., Butler H. (2014). Friends or foes? Relational dissonance and adolescent psychological wellbeing. PLoS One 9:e83388. doi: 10.1371/journal.pone.0083388
• Cao L., He C. (2013). Polarization of macrophages and microglia in inflammatory demyelination. Neurosci. Bull. 29 189-198. doi: 10.1007/s12264-013-1324-1320
• Choi J. W., Gardell S. E., Herr D. R., Rivera R., Lee C. W., Noguchi K., et al (2011). FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation. Proc. Natl. Acad. Sci. U.S.A. 108 751-756. doi: 10.1073/pnas.1014154108

Terms in the title (7)： CD38 ,  欠失 ,  脱髄 ,  マウスモデル ,  グリア ,  活性化 ,  神経炎症