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J-GLOBAL ID：201902288438993799   Reference number：19A2359876

Pharmacological Chaperones for the Treatment of α-Mannosidosis

α-マンノシドーゼ治療のための薬理学的シャペロン【JST・京大機械翻訳】

Author (7)： Risquez-Cuadro Rocio (Department of Organic Chemistry, Faculty of Chemistry, University of Sevilla, Spain) ,  Matsumoto Reimi (Organization for Research Initiative and Promotion, Tottori University, Japan) ,  Ortega-Caballero Fernando (Department of Organic Chemistry, Faculty of Chemistry, University of Sevilla, Spain) ,  Nanba Eiji (Organization for Research Initiative and Promotion, Tottori University, Japan) ,  Higaki Katsumi (Organization for Research Initiative and Promotion, Tottori University, Japan) ,  Garcia Fernandez Jose Manuel (Instituto de Investigaciones Quimicas (IIQ), CSIC-Universidad de Sevilla, Spain) ,  Ortiz Mellet Carmen (Department of Organic Chemistry, Faculty of Chemistry, University of Sevilla, Spain)
Material： Journal of Medicinal Chemistry  (J Med Chem)
Volume： 62  Issue： 12  Page： 5832-5843  Publication year： 2019 
JST Material Number： D0102A  ISSN： 0022-2623  CODEN： JMCMAR  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： α-Mannosidosis (AM) results fr...

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Thesaurus term： aglycone ,  *chaperone protein ,  lysosome ,  folding(morphology) ,  enzyme inhibition ,  variation(biology) ,  *therapy ,  enzyme ,  binding site ,  transfection ,  human(primates) ,  substrate(biochemistry) ,  pathological state ,  endosome ,  alpha-mannosidase ,  sterol ,  alicyclic alcohol

JST classification (2)： Synthesis of drugs  (GV01030F) ,  Structure-activity relationship of drugs  (GV01050B)

Substance index (1)： Cholesterol

Terms in the title (3)： 治療 ,  薬理学 ,  シャペロン