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J-GLOBAL ID：201902288705891286   Reference number：19A1861175

Ginger-Degraded Collagen Hydrolysate Exhibits Antidepressant Activity in Mice

ショウガ分解コラーゲン加水分解物はマウスにおいて抗うつ作用を示す

Author (8)： MIZUSHIGE Takafumi (Department of Applied Biological Chemistry, Faculty of Agriculture, Utsunomiya University) ,  NOGIMURA Dai (Department of Applied Biological Chemistry, Faculty of Agriculture, Utsunomiya University) ,  NAGAI Akitoshi (Department of Applied Biological Chemistry, Faculty of Agriculture, Utsunomiya University) ,  MITSUHASHI Haruka (Department of Applied Biological Chemistry, Faculty of Agriculture, Utsunomiya University) ,  TAGA Yuki (Nippi Research Institute of Biomatrix) ,  KUSUBATA Masashi (Nippi Research Institute of Biomatrix) ,  HATTORI Shunji (Nippi Research Institute of Biomatrix) ,  KABUYAMA Yukihito (Department of Applied Biological Chemistry, Faculty of Agriculture, Utsunomiya University)
Material： Journal of Nutritional Science and Vitaminology (Web)
Volume： 65  Issue： 3  Page： 251-257(J-STAGE)  Publication year： 2019 
JST Material Number： U1313A  ISSN： 1881-7742  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： depression(disease) ,...
Semi thesaurus term： mental stress ,...

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Author keywords (8)： food-derived peptide ,  depression ,  mental stress ,  hippocampus ,  monoamine neurotransmitter ,  neurotrophic factor ,  neural stem cell ,  corticosterone

JST classification (3)： Food chemistry,nutritional value  (FJ01020J) ,  Vegetables and processed vegetable products  (FJ11020O) ,  Basic research of psychotropic drugs  (GW03100Y)

Substance index (1)： Corticosterone

Reference (35)：

• 1) Kakoi C, Udo H, Matsukawa T, Ohnuki K. 2012. Collagen peptides enhance hippocampal neurogenesis and reduce anxiety related behavior in mice. Biomed Res 33: 273-279.
• 2) Taga Y, Kusubata M, Ogawa-Goto K, Hattori S. 2016. Efficient absorption of X-hydroxyproline (Hyp)-Gly after oral administration of a novel gelatin hydrolysate prepared using ginger protease. J Agric Food Chem 64: 2962-2970.
• 3) Taga Y, Kusubata M, Ogawa-Goto K, Hattori S. 2017. Identification of collagen-derived hydroxyproline (Hyp)-containing cyclic dipeptides with high oral bioavailability: Efficient formation of cyclo(X-Hyp) from X-Hyp-Gly-Type tripeptides by heating. J Agric Food Chem 65: 9514-9521.
• 4) Tanti A, Belzung C. 2010. Open questions in current models of antidepressant action. Br J Pharmacol 159: 1187-1200.
• 5) Eisch AJ, Petrik D. 2012. Depression and hippocampal neurogenesis: a road to remission? Science 338: 72-75.

Terms in the title (5)： ショウガ ,  分解 ,  コラーゲン加水分解物 ,  マウス ,  抗うつ作用