Art

J-GLOBAL ID：201902288929071640   Reference number：19A0254119

Design, Synthesis, and Blood-Brain Barrier Transport Study of Pyrilamine Derivatives as Histone Deacetylase Inhibitors

ヒストンデアセチラーゼ阻害剤としてのピリラミン誘導体の設計,合成および血液脳関門輸送研究【JST・京大機械翻訳】

Author (12)： Hiranaka Seiya (Department of Life Science and Biotechnology, Faculty of Chemistry, Materials and Bioengineering, Kansai University, Japan) ,  Tega Yuma (Faculty of Pharma-Sciences, Teikyo University, Japan) ,  Higuchi Kei (Faculty of Pharma-Sciences, Teikyo University, Japan) ,  Kurosawa Toshiki (Faculty of Pharma-Sciences, Teikyo University, Japan) ,  Deguchi Yoshiharu (Faculty of Pharma-Sciences, Teikyo University, Japan) ,  Arata Mayumi (Seed Compounds Exploratory Unit for Drug Discovery Platform, RIKEN Center for Sustainable Resource Science, Japan) ,  Ito Akihiro (Chemical Genomics Research Group, RIKEN Center for Sustainable Resource Science, Japan) ,  Ito Akihiro (School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Japan) ,  Yoshida Minoru (Chemical Genomics Research Group, RIKEN Center for Sustainable Resource Science, Japan) ,  Yoshida Minoru (Seed Compounds Exploratory Unit for Drug Discovery Platform, RIKEN Center for Sustainable Resource Science, Japan) ,  Nagaoka Yasuo (Department of Life Science and Biotechnology, Faculty of Chemistry, Materials and Bioengineering, Kansai University, Japan) ,  Sumiyoshi Takaaki (Department of Life Science and Biotechnology, Faculty of Chemistry, Materials and Bioengineering, Kansai University, Japan)
Material： ACS Medicinal Chemistry Letters
Volume： 9  Issue： 9  Page： 884-888  Publication year： 2018 
JST Material Number： W5043A  ISSN： 1948-5875  Document type： Article
Article type： 短報  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： We designed and synthesized a ...

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Thesaurus term： conjugation ,  *blood-brain barrier ,  substrate(biochemistry) ,  sensitivity ,  proton ,  *histone deacetylase ,  aromatic carboxylic acid ,  carboxamide
Semi thesaurus term： 透過性 ,  阻害活性 ,  *阻害剤 ,  対向輸送体 ,  有機カチオン ,  *ヒストンデアセチラーゼ阻害剤 , 【Automatic Indexing@JST】

Author keywords (5)： Histone deacetylase ,  HDAC inhibitor ,  blood-brain barrier ,  selective inhibitor ,  pyrilamine-sensitive proton-coupled organic cation antiporter

JST classification (1)： Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W)

Substance index (1)： Benzamide

Terms in the title (7)： ヒストンデアセチラーゼ阻害剤 ,  ピリラミン ,  誘導体 ,  設計 ,  血液脳関門 ,  輸送 ,  研究