Art

J-GLOBAL ID：201902290684968795   Reference number：19A2607609

Disease-associated mutations hyperactivate KIF1A motility and anterograde axonal transport of synaptic vesicle precursors

疾患関連突然変異はシナプス小胞前駆体のKIF1A運動性と順行性軸索輸送を高活性化する【JST・京大機械翻訳】

Author (9)： Chiba Kyoko (Department of Molecular and Cellular Biology, University of California, Davis, CA 95616) ,  Takahashi Hironori (Department of Anatomy and Structural Biology, Graduate School of Medicine, University of Yamanashi, Chuo, 409-3898 Yamanashi, Japan) ,  Chen Min (Department of System Information Sciences, Graduate School of Information Sciences, Tohoku University, Sendai, 980-8579 Miyagi, Japan) ,  Obinata Hiroyuki (Frontier Research Institute for Interdisciplinary Sciences, Tohoku University, Sendai, 980-0845 Miyagi, Japan) ,  Arai Shogo (Department of Robotics, Graduate School of Engineering, Tohoku University, Sendai, 980-8579 Miyagi, Japan) ,  Hashimoto Koichi (Department of System Information Sciences, Graduate School of Information Sciences, Tohoku University, Sendai, 980-8579 Miyagi, Japan) ,  Oda Toshiyuki (Department of Anatomy and Structural Biology, Graduate School of Medicine, University of Yamanashi, Chuo, 409-3898 Yamanashi, Japan) ,  McKenney Richard J. (Department of Molecular and Cellular Biology, University of California, Davis, CA 95616) ,  Niwa Shinsuke (Frontier Research Institute for Interdisciplinary Sciences, Tohoku University, Sendai, 980-0845 Miyagi, Japan)
Material： Proceedings of the National Academy of Sciences of the United States of America  (PNAS)
Volume： 116  Issue： 37  Page： 18429-18434  Publication year： 2019 
JST Material Number： D0387A  ISSN： 0027-8424  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： KIF1A is a kinesin family moto...

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Thesaurus term： in vitro experiment ,  neuropathy ,  motor ,  *synaptic vesicle ,  diplegia ,  Heredity ,  *Mutation ,  microtubule ,  convulsion ,  *axon ,  human ,  Kinesin ,  *Axonal Transport ,  Caenorhabditis elegans ,  *Genetic Variation ,  *membrane and film ,  *biomembrane ,  *Endomembrane system ,  Rhabditida ,  invertebrate
Semi thesaurus term： Caenorhabditis elegans ,  *variation(biology) , 【Automatic Indexing@JST】

Author keywords (5)： axonal transport ,  hereditary spastic paraplegia ,  kinesin ,  KIF1A ,  UNC-104

JST classification (2)： Cell physiology in general  (EF02010S) ,  Biological function  (EB03040U)

Terms in the title (8)： 疾患 ,  突然変異 ,  シナプス小胞 ,  前駆体 ,  KIF1A ,  運動性 ,  軸索輸送 ,  活性化