Art

J-GLOBAL ID：201902291512567158   Reference number：19A2931580

Ascorbic acid insufficiency impairs spatial memory formation in juvenile AKR1A-knockout mice

アスコルビン酸欠乏は幼若AKR1Aノックアウトマウスにおける空間記憶形成を損なう

Author (12)： Kurihara Kazuki (Department of Biochemistry and Molecular Biology, Graduate School of Medical Science, Yamagata University) ,  Kurihara Kazuki (Department of Anesthesiology, Faculty of Medicine, Yamagata University) ,  Homma Takujiro (Department of Biochemistry and Molecular Biology, Graduate School of Medical Science, Yamagata University) ,  Kobayashi Sho (Department of Biochemistry and Molecular Biology, Graduate School of Medical Science, Yamagata University) ,  Shichiri Mototada (Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST)) ,  Fujiwara Hiroki (Department of Physiology, Faculty of Medicine, Yamagata University) ,  Fujii Satoshi (Department of Physiology, Faculty of Medicine, Yamagata University) ,  Yamada Ken-ichi (Physical Chemistry for Life Science Laboratory, Faculty of Pharmaceutical Sciences, Kyushu University) ,  Yamada Ken-ichi (AMED-CREST, Japan Agency for Medical Research and Development) ,  Nakane Masaki (Department of Emergency and Critical Care Medicine, Faculty of Medicine, Yamagata University) ,  Kawamae Kaneyuki (Department of Anesthesiology, Faculty of Medicine, Yamagata University) ,  Fujii Junichi (Department of Biochemistry and Molecular Biology, Graduate School of Medical Science, Yamagata University)
Material： Journal of Clinical Biochemistry and Nutrition  (JCBN)
Volume： 65  Issue： 3  Page： 209-216(J-STAGE)  Publication year： 2019 
JST Material Number： X0851A  ISSN： 0912-0009  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： knockout mouse ,...
Semi thesaurus term： AKR1A遺伝子 ,...

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Author keywords (4)： ascorbic acid ,  AKR1A ,  Morris water maze ,  spatial memory

JST classification (2)： Basic neurology  (GN01020W) ,  Vitamin C  (EB07040W)

Substance index (1)： Ascorbic Acid

Reference (44)：

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• 2 Hess CR, McGuirl MM, Klinman JP. Mechanism of the insect enzyme, tyramine beta-monooxygenase, reveals differences from the mammalian enzyme, dopamine beta-monooxygenase. J Biol Chem 2008; 283: 3042-3049.
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• 4 Ballaz S, Morales I, Rodríguez M, Obeso JA. Ascorbate prevents cell death from prolonged exposure to glutamate in an in vitro model of human dopaminergic neurons. J Neurosci Res 2013; 91: 1609-1617.
• 5 Guo YE, Suo N, Cui X, Yuan Q, Xie X. Vitamin C promotes oligodendrocytes generation and remyelination. Glia 2018; 66: 1302-1316.

Terms in the title (3)： アスコルビン酸欠乏 ,  ノックアウトマウス ,  記憶形成