Art

J-GLOBAL ID：201902291664509148   Reference number：19A0979166

Design, synthesis and anti-malarial activities of synthetic analogs of biselyngbyolide B, a Ca²⁺ pump inhibitor from marine cyanobacteria

海産シアノバクテリア由来のCa2+ポンプ阻害剤,ビスエレグビオリドBの合成類似体の設計,合成および抗マラリア活性【JST・京大機械翻訳】

Author (10)： Sato Eisuke (Department of Chemistry, Faculty of Science and Technology, Keio University, Hiyoshi 3-14-1, Kohoku-ku, Yokohama 223-8522, Japan) ,  Morita Maho (Department of Chemistry, Faculty of Science and Technology, Keio University, Hiyoshi 3-14-1, Kohoku-ku, Yokohama 223-8522, Japan) ,  Morita Maho (Institute of Molecular and Cellular Bioscience, The University of Tokyo, Bunkyo-ku, Tokyo 113-0032, Japan) ,  Ogawa Haruo (Institute of Molecular and Cellular Bioscience, The University of Tokyo, Bunkyo-ku, Tokyo 113-0032, Japan) ,  Iwatsuki Masato (Research Center for Tropical Diseases, Kitasato Institute for Life Science, and Graduate School of Infection Control Science, Kitasato University, 5-9-1, Shirokane Minato-ku, Tokyo 108-8641, Japan) ,  Hokari Rei (Research Center for Tropical Diseases, Kitasato Institute for Life Science, and Graduate School of Infection Control Science, Kitasato University, 5-9-1, Shirokane Minato-ku, Tokyo 108-8641, Japan) ,  Ishiyama Aki (Research Center for Tropical Diseases, Kitasato Institute for Life Science, and Graduate School of Infection Control Science, Kitasato University, 5-9-1, Shirokane Minato-ku, Tokyo 108-8641, Japan) ,  Omura Satoshi (Research Center for Tropical Diseases, Kitasato Institute for Life Science, and Graduate School of Infection Control Science, Kitasato University, 5-9-1, Shirokane Minato-ku, Tokyo 108-8641, Japan) ,  Iwasaki Arihiro (Department of Chemistry, Faculty of Science and Technology, Keio University, Hiyoshi 3-14-1, Kohoku-ku, Yokohama 223-8522, Japan) ,  Suenaga Kiyotake (Department of Chemistry, Faculty of Science and Technology, Keio University, Hiyoshi 3-14-1, Kohoku-ku, Yokohama 223-8522, Japan)
Material： Bioorganic & Medicinal Chemistry Letters  (Bioorg Med Chem Lett)
Volume： 28  Issue： 3  Page： 298-301  Publication year： 2018 
JST Material Number： W0248A  ISSN： 0960-894X  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Biselyngbyaside, an 18-membere...

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Thesaurus term： *analogical material ,  Endoplasmic Reticulum ,  *Malaria ,  biological activity ,  aglycone ,  Structure-Activity Relationship ,  ATPase ,  Parasites ,  synthetic pathways ,  co-crystal ,  orthologue ,  *Cyanobacteriota ,  Plasmodium ,  *anti-malarial activity ,  *microorganism ,  *Plants ,  *Cryptogamae ,  protozoa ,  Sporozoa
Semi thesaurus term： *Cyanophyta ,  Plasmodium ,  *抗マラリア活性 ,  *阻害剤 , 【Automatic Indexing@JST】

Author keywords (5)： Biselyngbyaside ,  Biselyngbyolide ,  SERCA ,  PfATP6 ,  Structure-activity relationships

JST classification (2)： Structure-activity relationship of drugs  (GV01050B) ,  Synthesis of drugs  (GV01030F)

Terms in the title (6)： シアノバクテリア ,  Ca2+ポンプ ,  阻害剤 ,  類似体 ,  設計 ,  抗マラリア活性