Art

J-GLOBAL ID：201902296220801424   Reference number：19A2213983

Tyrosine-phosphorylated SOCS3 negatively regulates cellular transformation mediated by the myeloproliferative neoplasm-associated JAK2 V617F mutant

チロシンりん酸化SOCS3は骨髄増殖性腫瘍関連JAK2 V617F変異体により仲介される細胞形質転換を負に調節する【JST・京大機械翻訳】

Author (7)： Funakoshi-Tago Megumi (Division of Hygienic Chemistry, Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512, Japan) ,  Tsuruya Rina (Division of Hygienic Chemistry, Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512, Japan) ,  Ueda Fumihito (Division of Hygienic Chemistry, Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512, Japan) ,  Ishihara Aki (Division of Hygienic Chemistry, Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512, Japan) ,  Kasahara Tadashi (International University of Health and Welfare, Graduate School, 1-3-3 Minamiaoyama, Minato-ku, Tokyo 107-0062, Japan) ,  Tamura Hiroomi (Division of Hygienic Chemistry, Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512, Japan) ,  Tago Kenji (Division of Structural Biochemistry, Department of Biochemistry, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi-ken 329-0498, Japan)
Material： Cytokine
Volume： 123  Page： Null  Publication year： 2019 
JST Material Number： W0144A  ISSN： 1043-4666  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： In the majority of myeloprolif...

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Thesaurus term： gene ,  repressor ,  Cell Proliferation ,  interaction ,  Down-Regulation ,  *mutagenesis ,  phosphorylation ,  Point Mutation ,  Proteins ,  tumorigenesis ,  ERK ,  human ,  *SOCS ,  Gene Knockdown Technique ,  *SOCS3 ,  signal transduction pathway
Semi thesaurus term： 伝達経路 , 【Automatic Indexing@JST】

Author keywords (5)： JAK2 V617F mutant ,  Myeloproliferative neoplasms (MPNs) ,  SOCS3 ,  SH2 domain ,  Phosphorylation

JST classification (1)： Cytokines  (EB08090G)

Terms in the title (9)： チロシンりん酸化 ,  SOCS3 ,  骨髄増殖性腫瘍 ,  JAK2 ,  V617F ,  変異体 ,  仲介 ,  細胞形質転換 ,  調節