Art

J-GLOBAL ID：201902299970430672   Reference number：19A1125739

Catalytic asymmetric synthesis of stereoisomers of 1-C-n-butyl-LABs for the SAR study of α-glucosidase inhibition

α-グルコシダーゼ阻害のSAR研究のための1-C-n-ブチル-ラボの立体異性体の触媒的不斉合成【JST・京大機械翻訳】

Author (8)： Natori Yoshihiro (Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, Sendai, 981-8558, Japan) ,  Sakuma Toshihiro (Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, Sendai, 981-8558, Japan) ,  Watanabe Haruka (Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, Sendai, 981-8558, Japan) ,  Wakamatsu Hideaki (Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, Sendai, 981-8558, Japan) ,  Kato Atsushi (Department of Hospital Pharmacy, University of Toyama, Toyama, 930-0194, Japan) ,  Adachi Isao (Department of Hospital Pharmacy, University of Toyama, Toyama, 930-0194, Japan) ,  Takahata Hiroki (Faculty of Pharmaceutical Sciences, Tohoku Pharmaceutical University, Sendai, 981-8558, Japan) ,  Yoshimura Yuichi (Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, Sendai, 981-8558, Japan)
Material： Tetrahedron  (Tetrahedron Symposia-in-Print)
Volume： 75  Issue： 20  Page： 2866-2876  Publication year： 2019 
JST Material Number： E0234A  ISSN： 0040-4020  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： We achieved synthesis of seven...

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Thesaurus term： intermediate ,  *alpha-glucosidase ,  *catalyst ,  *isomer (molecule) ,  *glucosidase ,  glycosidic linkage hydrolase ,  diol ,  Alkylation ,  *stereoisomer ,  inhibitory activity ,  synthetic pathways ,  chirality ,  Negishi coupling ,  catalytic asymmetric synthesis
Semi thesaurus term： 阻害剤 , 【Automatic Indexing@JST】

Author keywords (3)： Stereoselective synthesis ,  Iminosugar ,  α-Glucosidase inhibitor

JST classification (1)： Amino acids  (CF10070V)

Terms in the title (8)： α-グルコシダーゼ ,  阻害 ,  SAR ,  研究 ,  N-ブチル ,  ラボ ,  立体異性体 ,  触媒的不斉合成