Research field (2)：
Functional biochemistry
, Bioorganic chemistry
Research keywords (3)：
Chemical synthesis
, Glycoconjugates
, Glycoprotein
Research theme for competitive and other funds (18)：
2022 - 2025 Creation of bioregulatory molecules stemmed from glucosylated glycoconjugates produced in the ER
2022 - 2025 Creation of bioactive molecules based on glucosylated glycoconjugates in the ER
2016 - 2021 Chemical Biology of ER Related Glycan Modifications
2014 - 2018 Structural and functional analysis of glycosidases from plants that have a novel active center
2017 - 2018 糖質を基本骨格とするエピジェネティック制御分子の創製
2013 - 2015 Application of selenocysteine for enhancement of the reactivity of the enzymes related on redox regulation system
2009 - 2015 伊藤グライコトリロジープロジェクト
2009 - 2013 脳機能改善を目的としたエピゲノム解析による創薬基盤
2007 - 2009 The experimental production of the drug delivery system using a bacterial-toxin infection mechanism.
2005 - 2009 Comprehensive Studies toward Synthesis of Glycoproteins
2005 - 2008 The function of glycoprotein receptors in the transit from ER to Golgi.
2002 - 2007 糖タンパク質品質管理における糖鎖機能の解明
2004 - 2006 新規な一時的保護基を用いる糖誘導体の合成
2004 - 2006 生物活性糖鎖迅速合成プロセスの開発
2001 - 2003 Organic Synthesis of Glycoprotein Structural Motifs
1997 - 1999 糖鎖の超精密合成に関する基礎研
1996 - 1998 Synthesis of Glycoconjugate Derived Glycans as Molecular Probes
1991 - 1996 糖鎖の構造・機能解析のための共通基盤技術の開発に関する研究
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Papers (456)：
Akito Taira, Makoto Hirano, Taiki Kuribara, Chie Watanabe, Satoshi Hiraki, Mitsuaki Hirose, Zalihe Hakki, Spencer J. Williams, Yukishige Ito, Kiichiro Totani. Chemical Probe Approach Reveals Endo-α-mannosidase Triages Misfolded Glycoproteins in the Calnexin/Calreticulin Cycle. ACS Chemical Biology. 2025
Hirotaka Tomii, Takashi Kikuma, Hiroyuki Kajiura, Kanae Sano, Hiroyoshi Matsumura, Yukishige Ito, Yasuhiro Kajihara, Yoichi Takeda. Expression, purification, and enzymatic characterization of human UDP-glucose:glycoprotein glucosyltransferase-selenoprotein F complex from Sf9 insect cells. Protein Expression and Purification. 2025. 231. 106719-106719
Akihiro Ishiwata, Yurina Shite, Kanefumi Kitahara, Katsunori Tanaka, Yukishige Ito, Kiyotaka Fujita. Structural analysis of (2 → 1)-β-d-fructofuranosides linked to a terminal difructose dianhydride III produced by Bacteroides endo-type inulin fructotransferase. International journal of biological macromolecules. 2025. 143064-143064
Yumeka Iguchi, Akari Horiguchi, Miran Nakano, Megumi Maeda, Akihiro Ishiwata, Yukishige Ito, Yoshinobu Kimura. Free <i>N</i>-glycans occurring in plant extracellular fluid or cytosol interact with an auxin, indole-3-acetic acid: Putative biofunction of free <i>N</i>-glycans in plants. Plant Biotechnology. 2025. 42. 1. 79-85
石渡明弘, 志手由里奈, 北原兼文, 藤田清貴, 田中克典, 田中克典, 伊藤幸成, 伊藤幸成. Analysis of production mechanism of oligofructofranoside with reducing terminal DFA III by inuline-degrading enzyme from B. caccae. 日本化学会春季年会講演予稿集(Web). 2025. 105th
石渡明弘, 志手由里奈, 北原兼文, 藤田清貴, 田中克典, 田中克典, 伊藤幸成, 伊藤幸成. Proposed mechanism of formation of DFA III-containing degradation products by glycoside hydrolase family 91 inulin-degrading enzyme. 日本農芸化学会大会講演要旨集(Web). 2025. 2025
石渡明弘, 藤田清貴, 福島陸, 鹿島騰真, 鹿島騰真, 伏信進矢, 伏信進矢, 田中克典, 田中克典, 伊藤幸成, et al. Study on analysis of mechanism of β-D-arabinofuranosidase using inhibitor probes. 日本糖質学会年会要旨集. 2024. 43rd
石渡明弘, 佐々木優紀, 佐々木優紀, 松尾綾子, 橋口実々花, 藤村花乃子, 北原兼文, 藤田清貴, 越野広雪, 田中克典, et al. Structural analysis of oligosaccharides cleaved from gum arabic AGP of Acacia seyal by a novel Bifidobacterial glycosidase. 日本農芸化学会大会講演要旨集(Web). 2024. 2024
1977 - 1982 The University of Tokyo Graduate School of Pharmaceutical Sciences
1975 - 1977 The University of Tokyo Faculty of Pharmaceutical Sciences
1973 - 1975 The University of Tokyo College of Arts and Sciences
1970 - 1973 Nada High School
Professional career (1)：
Ph.D. (The University of Tokyo)
Work history (9)：
2020/04 - 現在 RIKEN Visiting Scientist
2020/04 - 現在 RIKEN Honorary Scientist
2020/04 - 現在 Osaka University Graduate School of Science Specially Appointed Professor
1998/12 - 2020/03 RIKEN Chief Scientist
2013/06 - 2018/12 American Chemical Society Associate Editor, ACS Chemical Biology
2009/10 - 2016/03 Japan Science and Technology Agency ERATO Glycotrilogy Project Research Director
1996/08 - 1998/11 RIKEN Senior Scientist
1984/04 - 1996/07 RIKEN Research Scientist
1982/04 - 1984/03 Massachusetts Institute of Technology Postdoctoral Research Associate
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Awards (8)：
2021/08 - American Chemical Society 2021 Claude S. Hudson Award
2017/02 - The Society of Synthetic Organic Chemistry, Japan Synthetic Organic Chemistry Award, Japan
2015/07 - 日本農芸化学会 フェロー
2012/03 - Japan Society for Bioscience, Biotechnology and Agrochemistry Japan Society for Bioscience, Biotechnology and Agrochemistry Award
2010/07 - Takeda Award for International Achievements
2010/03 - 理化学研究所 重要業績表彰
2008/07 - Roy L. Whistler International Award in Carbohydrate Chemistry
1993/03 - Japan Society for Bioscience, Biotechnology and Agrochemistry Japan Society for Bioscience, Biotechnology and Agrochemistry Award for Young Scientists
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Association Membership(s) (6)：
The Japanese Biochemical Society
, The Japanese Society of Carbohydrate Research
, Synthetic Organic Chemistry Society, Japan
, The American Chemical Society
, The Chemical Society of Japan
, Japan Society for Bioscience, Biotechnology, and Agrochemistry
