Kono Yohei

コウノヨウヘイ | Kono Yohei

Affiliation and department：
Job title： Postdoc
Homepage URL (1)： http://researchgate.net/profile/yohei-kono-3

Research field (4)： Cell biology , Molecular biology , Genomics , Applied molecular and cellular biology

Research keywords (25)： Cell Nucleus , Nuclear Envelope , Nuclear Lamina , Lamin , Chromatin Structure , Live cell imaging , Progeria , Molecular and Genetic Medicine , Regenerative Medicine , Cell Engineering , Genetic Engineering , Viral Vector , shRNA , Cell Sheet , Cell Transplantation , Mesenchymal Stem Cell , iPS Cells , Differentiation , Fibrosis , Cancer Stem Cells , Drug Screening , Hepatitis , Non-Alcoholic Steato-Hepatitis , Nuclear Receptors , Biostatistics

Research theme for competitive and other funds (2)：

2020 - 2025 細胞シート工学を用いたラミノパチー疾患モデル構築と核ラミナ修復機構の解明
2015 - 2018 Development of an early identification system for human hepatic differentiation tropic iPS cells focusing on glycosylation

Papers (16)：

Yohei Kono, Takeshi Shimi. Crosstalk between mitotic reassembly and repair of the nuclear envelope. Nucleus. 2024
Yohei Kono, Chan-Gi Pack, Takehiko Ichikawa, Arata Komatsubara, Stephen A Adam, Keisuke Miyazawa, Loïc Rolas, Sussan Nourshargh, Ohad Medalia, Robert D Goldman, et al. Roles of the lamin A-specific tail region in the localization to sites of nuclear envelope rupture. PNAS Nexus. 2024
Yohei Kono, Takeshi Shimi. Defective nuclear envelope repair in laminopathies. Journal of Japanese Biochemical Society. 2024. 96. 1. 101-105
Yohei Kono, Chan-Gi Pack, Takehiko Ichikawa, Arata Komatsubara, Stephen A. Adam, Keisuke Miyazawa, Loïc Rolas, Sussan Nourshargh, Ohad Medalia, Robert D. Goldman, et al. Delayed localization of A-type lamins to the rupture sites in Hutchinson-Gilford progeria syndrome. bioRxiv. 2023
Yohei Kono, Stephen A. Adam, Yuko Sato, Karen L. Reddy, Yixian Zheng, Ohad Medalia, Robert D. Goldman, Hiroshi Kimura, Takeshi Shimi. Nucleoplasmic lamin C rapidly accumulates at sites of nuclear envelope rupture with BAF and cGAS. Journal of Cell Biology. 2022. 221. 12

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MISC (71)：

Mohammad Mubarak Hosain, Yohei Kono, Keisuke Miyazawa, Takehiko Ichikawa, Takeshi Shimi, Takeshi Fukuma. Nanoendoscopy-AFM: A Novel Technique for Intracellular Imaging and Measurement of Mechanical Properties. 2024 Materials Research Society (MRS) Fall Meeting & Exhibit. 2024
川瀬雅貴, 河野洋平, 市川壮彦, 木村宏, 福間剛士, 眞貝洋一, 志見剛. 細胞核の力学的特性はヘテロクロマチン構造によって強化される. 日本遺伝学会第96回大会. 2024. O3-4
Yohei Kono, Tatsuya Niwa, Yixian Zheng, Stephen A. Adam, Robert D. Goldman, Hiroshi Kimura, Takeshi Shimi. Establishment and analysis of immortalized mouse embryonic fibroblasts lacking all lamins. 日本細胞生物学会大会講演要旨集 76回. 2024. 3P20
Alexis S. Borowiak, T. Ichikawa, M. Itou, T. Shimi, Y. Kono, R. Nitta, T. Fukuma. Mechanical properties of hiPSC derived-cardiomyocytes: investigating beating and non-beating cell’s nucleus via Nanoendoscopy-AFM. 21st International Union of Pure and Applied Biophysics and 62nd Biophysics Society of Japan (IUPAB-BSJ 2024). 2024. 26P-252
Alexis S. Borowiak, K. Sivashanmugan, T. Ichikawa, E. Hirata, T. Shimi, Y. Kono, T. Fukuma. New approaches to directly image the surface of the nucleus at nanometer scale. European Materials Research Society (E-MRS) 2024 Spring Meeting. 2024. 12_1845

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Patents (24)：

Zellblatt mit fibrose-inhibierender wirkung
Fibrosis-inhibiting composition, cells producing same, and cell sheet comprising said cells
Cell sheet having fibrosis inhibitory action
具有纖維化抑制作用之細胞層片
Inhibitory effect of low molecular weight compound on cancer and fibrosis

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Books (2)：

月刊薬事 2020年1月臨時増刊号ここがキモ! いまはこうする肝疾患vs.薬物療法肝機能評価&薬物性肝障害マネジメントに強くなる
株式会社じほう 2020
再生医療-日本再生医療学会雑誌
メディカルレビュー社 2014 ISBN:9784779213830

Lectures and oral presentations (2)：

Regenerative therapy for liver fibrosis using IC-2-engineered mesenchymal stem cell sheets
(The 8th Meeting of the International Federation for Artificial Organs 2019)
Nuclear receptor gene expression during hepatic differentiation from human induced pluripotent stem cells with hepatic differentiation propensity
(The 18th Takeda Science Foundation Symposium on Bioscience 2015)

Education (2)：

2011 - 2020 Tottori University Graduate School of Medicine Institute of Regenerative Medicine and Biofunction
2007 - 2011 Tottori University Faculty of Medicine School of Life Science

Work history (8)：

2024/04 - 現在 Kanazawa University Nano Life Science Institute (WPI-NanoLSI) Postdoc
2023/08 - 2024/03 Kanazawa University Institute of Science and Engineering Faculty of Frontier Engineering Postdoc
2020/01 - 2023/03 Tokyo Institute of Technology Cell Biology Center, Institute of Innovative Research Research Staff
2018/11 - 2019/12 Tottori University Department of Genetic Medicine and Regenerative Therapeutics, Graduate School of Medicine Assistant Professor (without tenure)
2017/04 - 2018/10 KanonCure, Inc. Startup company from Tottori University Representative director and Reseacher (self-employment)

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Awards (3)：

2024/02 - Sartorius Japan Winner at 13th Pipetting Contest Produced by Sartorius Japan, Record:0.05%
2022/06 - Japan Society for Cell Biology Young Scientist Award for Presentation 2022 Nucleoplasmic Lamin C Rapidly Accumulates at Sites of Nuclear Envelope Rupture
2010/02 - Japan Association of Biotechnology Education Top Scorers in the 15th Biotechnologist Certification [Upper Grade]

Association Membership(s) (5)：

Japan Society for Cell Biology , The Molecular Biology Society of Japan , The Japanese Society for Regenerative Medicine , The Japan Society of Hepatology , The Japanese Society for the Research of Hepatic Cells

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