Art

J-GLOBAL ID：202002210357403257   Reference number：20A0189213

Inhibition of microtubule assembly competent tubulin synthesis leads to accumulation of phosphorylated tau in neuronal cell bodies

神経細胞体におけるリン酸化タウの蓄積につながる微小管集合能チューブリン合成の阻害【JST・京大機械翻訳】

Author (10)： Fujiwara Hitomi (Department of Neuropathology, Faculty of Life and Medical Sciences, Doshisha University, Kyoto, 610-0394, Japan) ,  Watanabe Shoji (Laboratory of Ion Channel Pathophysiology, Graduate School of Brain Science, Doshisha University, Kyoto, 610-0394, Japan) ,  Iwata Minori (Laboratory of Ion Channel Pathophysiology, Graduate School of Brain Science, Doshisha University, Kyoto, 610-0394, Japan) ,  Ueda Shouyou (Department of Neuropathology, Faculty of Life and Medical Sciences, Doshisha University, Kyoto, 610-0394, Japan) ,  Nobuhara Mika (Department of Neuropathology, Faculty of Life and Medical Sciences, Doshisha University, Kyoto, 610-0394, Japan) ,  Wada-Kakuda Satoko (Department of Neuropathology, Faculty of Life and Medical Sciences, Doshisha University, Kyoto, 610-0394, Japan) ,  Misonou Hiroaki (Laboratory of Ion Channel Pathophysiology, Graduate School of Brain Science, Doshisha University, Kyoto, 610-0394, Japan) ,  Misonou Hiroaki (Center for Research in Neurodegenerative Diseases, Doshisha University, Kyoto, 610-0394, Japan) ,  Miyasaka Tomohiro (Department of Neuropathology, Faculty of Life and Medical Sciences, Doshisha University, Kyoto, 610-0394, Japan) ,  Miyasaka Tomohiro (Center for Research in Neurodegenerative Diseases, Doshisha University, Kyoto, 610-0394, Japan)
Material： Biochemical and Biophysical Research Communications  (BBRC)
Volume： 521  Issue： 3  Page： 779-785  Publication year： 2020 
JST Material Number： B0118A  ISSN： 0006-291X  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Neurofibrillary tangles, a pat...

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Thesaurus term： Acetylation ,  neurotoxicity ,  Alzheimer Disease ,  dendrite (neuron) ,  microtubule-associated protein ,  biosynthesis ,  homeostasis ,  *phosphorylation ,  in vitro experiment ,  chaperone protein ,  *microtubule ,  *Tubulin ,  neurofibril ,  Mammalia ,  pathogenesis ,  *Proteins ,  Vertebrata

Author keywords (5)： Tau ,  Tubulin ,  Tbce ,  Alzheimer’s disease ,  Tauopathy

JST classification (1)： Cell physiology in general  (EF02010S)

Terms in the title (9)： 神経 ,  細胞体 ,  リン酸化 ,  蓄積 ,  微小管 ,  集合 ,  能 ,  チューブリン ,  阻害