Art

J-GLOBAL ID：202002211789288850   Reference number：20A0149196

Vasodilator oxyfedrine inhibits aldehyde metabolism and thereby sensitizes cancer cells to xCT-targeted therapy

血管拡張薬オキシフェドリンはアルデヒド代謝を阻害し,それにより癌細胞をxCT標的治療に対し感作する

Author (7)： Otsuki Yuji (Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan) ,  Yamasaki Juntaro (Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan) ,  Suina Kentaro (Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan) ,  Okazaki Shogo (Division of Development and Aging, Research Institute for Biomedical Sciences, Tokyo University of Science, Noda, Japan) ,  Koike Naoyoshi (Department of Radiology, Keio University School of Medicine, Tokyo, Japan) ,  Saya Hideyuki (Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan) ,  Nagano Osamu (Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan)
Material： Cancer Science (Web)  (Cancer Sci (Web))
Volume： 111  Issue： 1  Page： 127-136  Publication year： 2020 
JST Material Number： U0505A  ISSN： 1349-7006  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： aldehyde ,...
Semi thesaurus term： シスチン-グルタミン酸対向輸送体阻害剤 ,...

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Author keywords (5)： aldehyde dehydrogenase (ALDH) ,  drug repurposing ,  ferroptosis ,  glutathione (GSH) ,  xCT

JST classification (2)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Experimental treatment for tumors  (GE02040Y)

Substance index (3)： Oxyfedrine ,  Glutathione ,  Salazosulfapyridine

Terms in the title (9)： 血管拡張薬 ,  オキシフェドリン ,  アルデヒド ,  代謝 ,  阻害 ,  癌細胞 ,  xCT ,  標的治療 ,  感作