Art

J-GLOBAL ID：202002212589966405   Reference number：20A0996188

Therapeutic drug monitoring of regorafenib and its metabolite M5 can predict treatment efficacy and the occurrence of skin toxicities

レゴラフェニブとその代謝産物M5の治療薬モニタリングは治療効果と皮膚毒性の発生を予測できる

Author (12)： Taguchi Daiki (Department of Clinical Oncology, Akita University Graduate School of Medicine, Akita, Japan) ,  Inoue Masahiro (Department of Clinical Oncology, Akita University Graduate School of Medicine, Akita, Japan) ,  Fukuda Koji (Department of Clinical Oncology, Akita University Graduate School of Medicine, Akita, Japan) ,  Yoshida Taichi (Department of Clinical Oncology, Akita University Graduate School of Medicine, Akita, Japan) ,  Shimazu Kazuhiro (Department of Clinical Oncology, Akita University Graduate School of Medicine, Akita, Japan) ,  Fujita Kazuma (Department of Pharmacy, Akita University Hospital, Akita, Japan) ,  Okuyama Hiroyuki (Department of Clinical Oncology, Kagawa University, Kagawa, Japan) ,  Matsuhashi Nobuhisa (Department of Surgical Oncology, Gifu University Graduate School of Medicine, Gifu, Gifu, Japan) ,  Tsuji Akihito (Department of Clinical Oncology, Kagawa University, Kagawa, Japan) ,  Yoshida Kazuhiro (Department of Surgical Oncology, Gifu University Graduate School of Medicine, Gifu, Gifu, Japan) ,  Miura Masatomo (Department of Pharmacy, Akita University Hospital, Akita, Japan) ,  Shibata Hiroyuki (Department of Clinical Oncology, Akita University Graduate School of Medicine, Akita, Japan)
Material： International Journal of Clinical Oncology (Web)
Volume： 25  Issue： 4  Page： 531-540  Publication year： 2020 
JST Material Number： U1599A  ISSN： 1341-9625  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： metabolite ,...
Semi thesaurus term： Drug Monitoring ,...

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Author keywords (5)： Colorectal cancer ,  Gastrointestinal stromal tumor ,  C_trough ,  Regorafenib ,  Therapeutic drug monitoring

JST classification (3)： Clinical application of antitumor(=antineoplastic)drugs  (GW16020L) ,  Skin diseases  (GF03000Q) ,  Clinical biopharmacy  (GY01022L)

Substance index (1)： Regorafenib

Terms in the title (7)： レゴラフェニブ ,  代謝産物 ,  治療薬 ,  モニタリング ,  治療効果 ,  皮膚毒性 ,  予測