Art

J-GLOBAL ID：202002217173245449   Reference number：20A1762202

Crystal Structure of Catechol O-Methyltransferase Complexed with Nitecapone

ニテカポンと複合体を形成したカテコールO-メチルトランスフェラーゼの結晶構造

Author (8)： Iijima Hiroshi (School of Pharmacy, Nihon University) ,  Takebe Katsuki (Oral and Maxillofacial Surgery II, Osaka University Graduate School of Dentistry) ,  Suzuki Mamoru (Institute for Protein Research, Osaka University) ,  Kobayashi Hiroko (School of Pharmacy, Nihon University) ,  Takamiya Tomoko (School of Pharmacy, Nihon University) ,  Saito Hiroaki (School of Pharmacy, Nihon University) ,  Niwa Norio (School of Pharmacy, Nihon University) ,  Kuwada-Kusunose Takao (School of Dentistry at Matsudo, Nihon University)
Material： Chemical and Pharmaceutical Bulletin (Web)
Volume： 68  Issue： 5  Page： 447-451(J-STAGE)  Publication year： 2020 
JST Material Number： U1401A  ISSN： 1347-5223  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *catechol methyltransferase ,...
Semi thesaurus term： Catechol O-Methyltransferase ,...

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Author keywords (6)： catechol O-methyltransferase ,  nitecapone ,  crystal structure ,  catechol O-methyltransferase ,  nitecapone ,  crystal structure

JST classification (3)： Molecular structure  (EB03020Y) ,  Enzyme in general  (EB09010D) ,  Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W)

Substance index (6)： S-Adenosylhomocysteine ,  S-Adenosylmethionine ,  Entacapone ,  Catechol ,  Tolcapone ,  Nitecapone

Reference (15)：

• 1) “International review of neurobiology Vol. 95, Basic aspect of catechol-O-methyltransferase and clinical applications of its inhibitors,” ed. by Nissen E., Academic Press, Cambridge, MA, 2010.
• 2) Eggert K., Skogar Ö., Amar K., Luotonen L., Kuoppamäki M., Leinonen M., Nissinen H., Oertel W., J. Neural Transm. (Vienna), 117, 333-342 (2010).
• 3) Müller T., Kuhn W., Eur. J. Clin. Pharmacol., 62, 447-450 (2006).
• 4) O’Tuathaigh C. M., Desbonnet L., Lee P., Waddington J. L., CNS Neurol. Disord. Drug Targets, 11, 282-291 (2012).
• 5) Marsala S. Z., Gioulis M., Ceravolo R., Tinazzi M., Clin. Neuropharmacol., 35, 185-190 (2012).

Terms in the title (4)： ニテカポン ,  複合体 ,  カテコールO-メチルトランスフェラーゼ ,  結晶構造