Art

J-GLOBAL ID：202002217391858526   Reference number：20A0526079

Progranulin deficiency leads to enhanced age-related cardiac hypertrophy through complement C1q-induced β-catenin activation

プログランリン欠損は補体C1q誘導βカテニン活性化を介して加齢関連心臓肥大を促進する【JST・京大機械翻訳】

Author (16)： Zhu Yinghong (Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Ohama Tohru (Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Ohama Tohru (Department of Dental Anesthesiology, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Kawase Ryota (Department of Cardiology, Sousei Hospital, 596 Oazayokochi, Kadoma, Osaka 571-0025, Japan) ,  Chang Jiuyang (Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Inui Hiroyasu (Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Kanno Kotaro (Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Okada Takeshi (Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Okada Takeshi (Department of Community Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Masuda Daisaku (Rinku General Medical Center, 2-23 Ohrai-kita, Izumisano, Osaka 598-8577, Japan) ,  Koseki Masahiro (Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Nishida Makoto (Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Nishida Makoto (Health and Counselling Centre, Osaka University, 1-7 Machikaneyama, Toyonaka, Osaka 560-0043, Japan) ,  Sakata Yasushi (Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Yamashita Shizuya (Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Yamashita Shizuya (Rinku General Medical Center, 2-23 Ohrai-kita, Izumisano, Osaka 598-8577, Japan)
Material： Journal of Molecular and Cellular Cardiology  (J Mol Cell Cardiol)
Volume： 138  Page： 197-211  Publication year： 2020 
JST Material Number： E0538A  ISSN： 0022-2828  CODEN： JMCDAY  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Age-related cardiac hypertroph...

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Thesaurus term： tibia ,  *complement (immunology) ,  senile change ,  dysfunction ,  cardiac insufficiency ,  old age ,  cross section (area) ,  ablation ,  *catenin ,  echocardiography ,  *cardiac hypertrophy ,  Lipofuscin ,  wild type ,  *Heart ,  Cardiac Myocyte ,  bone of leg ,  *Proteins

Author keywords (5)： Progranulin ,  Senescence ,  Age-related cardiac hypertrophy ,  Complement C1q ,  β-Catenin

JST classification (1)： Basic medicine on cardiovascular system  (GJ01020K)

Terms in the title (9)： 欠損 ,  補体 ,  C1q ,  誘導 ,  βカテニン ,  活性化 ,  加齢 ,  心臓肥大 ,  促進