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J-GLOBAL ID：202002219446446445   Reference number：20A0116881

Effect of Yokukansan and Yokukansankachimpihange on Aggressive Behavior, 5-HT Receptors and Arginine Vasopressin Expression in Social Isolation-Reared Mice

社会的孤立飼育マウスにおける攻撃行動,5-HT受容,体およびアルギニンバソプレシン発現に対する抑肝散および抑肝散加陳皮半夏の効果

Author (13)： Iba Hikari (Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University) ,  Watanabe Takuya (Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University) ,  Watanabe Takuya (A.I.G. Collaborative Research Institute for Aging and Brain Sciences, Fukuoka University) ,  Matsuzawa Kanae (Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University) ,  Saimiya Maki (Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University) ,  Tanaka Masako (Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University) ,  Nagao Masaki (A.I.G. Collaborative Research Institute for Aging and Brain Sciences, Fukuoka University) ,  Moriyama Hiroshi (Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University) ,  Kubota Kaori (Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University) ,  Kubota Kaori (A.I.G. Collaborative Research Institute for Aging and Brain Sciences, Fukuoka University) ,  Katsurabayashi Shutaro (Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University) ,  Iwasaki Katsunori (Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University) ,  Iwasaki Katsunori (A.I.G. Collaborative Research Institute for Aging and Brain Sciences, Fukuoka University)
Material： Biological and Pharmaceutical Bulletin (Web)
Volume： 42  Issue： 12  Page： 2009-2015(J-STAGE)  Publication year： 2019 
JST Material Number： U1402A  ISSN： 1347-5215  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： Mus musculus ,...
Semi thesaurus term： amygdaloid nucleus ,...

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Author keywords (10)： yokukansan ,  yokukansankachimpihange ,  aggressive behavior ,  arginine vasopressin ,  serotonin (5-HT)_3A receptor ,  yokukansan ,  yokukansankachimpihange ,  aggressive behavior ,  arginine vasopressin ,  serotonin (5-HT)_3A receptor

JST classification (2)： Oriental medicine  (GA04000I) ,  Basic research of pharmacology of crude drugs  (GX06020J)

Substance index (1)： 5-Hydroxyindoleacetic acid

Reference (41)：

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• 3) Pinna G, Dong E, Matsumoto K, Costa E, Guidotti A. In socially isolated mice, the reversal of brain allopregnanolone down-regulation mediates the anti-aggressive action of fluoxetine. Proc. Natl. Acad. Sci. U.S.A., 100, 2035-2040 (2003).
• 4) Koike H, Ibi D, Mizoguchi H, Nagai T, Nitta A, Takuma K, Nabeshima T, Yoneda Y, Yamada K. Behavioral abnormality and pharmacologic response in social isolation-reared mice. Behav. Brain Res., 202, 114-121 (2009).
• 5) Takeda A, Iwaki H, Ide K, Tamano H, Oku N. Therapeutic effect of Yokukansan on social isolation-induced aggressive behavior of zinc-deficient and pair-fed mice. Brain Res. Bull., 87, 551-555 (2012).

Terms in the title (10)： 社会的孤立 ,  飼育 ,  マウス ,  攻撃行動 ,  5-HT ,  受容 ,  アルギニンバソプレシン ,  発現 ,  抑肝散 ,  抑肝散加陳皮半夏