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J-GLOBAL ID：202002219574296535   Reference number：20A1742484

SAMHD1-mediated dNTP degradation is required for efficient DNA repair during antibody class switch recombination

SAMHD1仲介dNTP分解は抗体クラススイッチ組換え時の効率的なDNA修復に必要である【JST・京大機械翻訳】

Author (10)： Husain Afzal (Department of Immunology and Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan) ,  Xu Jianliang (Department of Immunology and Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan) ,  Fujii Hodaka (Department of Biochemistry and Genome Biology, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, Japan) ,  Fujii Hodaka (Combined Program on Microbiology and Immunology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan) ,  Nakata Mikiyo (Department of Immunology and Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan) ,  Kobayashi Maki (Department of Immunology and Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan) ,  Wang Ji-Yang (Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China) ,  Rehwinkel Jan (Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK) ,  Honjo Tasuku (Department of Immunology and Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan) ,  Begum Nasim A (Department of Immunology and Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan)
Material： EMBO Journal  (EMBO J)
Volume： 39  Issue： 15  Page： e102931  Publication year： 2020 
JST Material Number： A0911B  ISSN： 0261-4189  CODEN： EMJODG  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Sterile alpha motif and histid...

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Thesaurus term： enzyme ,  Hydrolysis ,  *DNA ,  Heredity ,  immunoglobulin ,  *antibody ,  nucleotide ,  Autoimmunity ,  *DNA Repair ,  translocation (genetics) ,  brain disease ,  Genomic Instability ,  domain structure ,  controlling element ,  *class switch recombination ,  cellular genetic phenomenon

Author keywords (5)： AICDA ,  DNA repair ,  dNTP ,  genomic instability ,  SAMHD1

JST classification (2)： Function of cell components  (EF03060C) ,  Cell physiology in general  (EF02010S)

Terms in the title (7)： SAMHD1 ,  仲介 ,  DNTP ,  分解 ,  抗体 ,  クラススイッチ組換え ,  DNA修復