Art

J-GLOBAL ID：202002221429627162   Reference number：20A2761968

Human iPS cell-derived mural cells as an in vitro model of hereditary cerebral small vessel disease

遺伝性脳小血管疾患のin vitroモデルとしてのヒトiPS細胞由来壁細胞【JST・京大機械翻訳】

Author (27)： Yamamoto Yumi (Research Fellow of Japan Society for the Promotion of Science, Tokyo, Japan) ,  Yamamoto Yumi (Department of Molecular Innovation in Lipidemiology, National Cerebral and Cardiovascular Center Research Institute, Suita-shi, Japan) ,  Kojima Katsutoshi (Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan) ,  Taura Daisuke (Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan) ,  Sone Masakatsu (Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan) ,  Washida Kazuo (Department of Stroke and Cerebrovascular Diseases, National Cerebral and Cardiovascular Center, Suita-shi, Japan) ,  Egawa Naohiro (Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan) ,  Egawa Naohiro (iPSC-based Drug Discovery and Development Team, RIKEN BioResource Research Center (BRC), Kyoto, Japan) ,  Egawa Naohiro (Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan) ,  Kondo Takayuki (Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan) ,  Kondo Takayuki (iPSC-based Drug Discovery and Development Team, RIKEN BioResource Research Center (BRC), Kyoto, Japan) ,  Kondo Takayuki (Medical-risk Avoidance based on iPS Cells Team, RIKEN Center for Advanced Intelligence Project (AIP), Kyoto, Japan) ,  Minakawa Eiko N. (Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan) ,  Tsukita Kayoko (Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan) ,  Tsukita Kayoko (iPSC-based Drug Discovery and Development Team, RIKEN BioResource Research Center (BRC), Kyoto, Japan) ,  Enami Takako (Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan) ,  Enami Takako (Medical-risk Avoidance based on iPS Cells Team, RIKEN Center for Advanced Intelligence Project (AIP), Kyoto, Japan) ,  Tomimoto Hidekazu (Department of Dementia Prevention and Therapeutics, Graduate School of Medicine, Mie University, Mie, Japan) ,  Mizuno Toshiki (Department of Neurology, Kyoto Prefectural University of Medicine, Kyoto, Japan) ,  Kalaria Raj N. (Neurovascular Research Group, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK) ,  Inagaki Nobuya (Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan) ,  Takahashi Ryosuke (Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan) ,  Harada-Shiba Mariko (Department of Molecular Innovation in Lipidemiology, National Cerebral and Cardiovascular Center Research Institute, Suita-shi, Japan) ,  Ihara Masafumi (Department of Stroke and Cerebrovascular Diseases, National Cerebral and Cardiovascular Center, Suita-shi, Japan) ,  Inoue Haruhisa (Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan) ,  Inoue Haruhisa (iPSC-based Drug Discovery and Development Team, RIKEN BioResource Research Center (BRC), Kyoto, Japan) ,  Inoue Haruhisa (Medical-risk Avoidance based on iPS Cells Team, RIKEN Center for Advanced Intelligence Project (AIP), Kyoto, Japan)
Material： Molecular Brain (Web)
Volume： 13  Issue： 1  Page： 1-12  Publication year： 2020 
JST Material Number： U7335A  ISSN： 1756-6606  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： Cerebral autosomal dominant ar...

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Thesaurus term： *heredity ,  mutation ,  differentiation(biology) ,  cortex(animal tissue) ,  pathogenicity ,  dominance ,  *vascular disease ,  deposition ,  arteriole ,  autosome ,  *parietal cell ,  endothelial cell ,  therapeutic planning ,  infarct ,  pathogenesis

Author keywords (7)： CADASIL ,  Notch3 ,  Mural cell ,  PDGFRβ ,  Induced pluripotent stem cell ,  Differentiation ,  Cerebral small vessel disease

JST classification (2)： Nervous system diseases  (GN03000O) ,  Cardiovascular system diseases  (GJ03000C)

Reference (40)：

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• Mech Dev; Vascular expression of notch pathway receptors and ligands is restricted to arterial vessels; N Villa, L Walker, CE Lindsell, J Gasson, ML Iruela-Arispe, G Weinmaster; 108; 2001; 1-2; 10.1016/S0925-4773(01)00469-5; citation_id=CR2
• Brain Pathol; Quantitative vascular pathology and phenotyping familial and sporadic cerebral small vessel diseases; LJL Craggs, C Hagel, G Kuhlenbaeumer, A Borjesson-Hanson, O Andersen, M Viitanen; 23; 2013; 547-557; 10.1111/bpa.12041; citation_id=CR3
• Stroke; Neuropathological correlates of temporal pole white matter hyperintensities in CADASIL; Y Yamamoto, M Ihara, C Tham, WC Low, JY Slade, T Moss; 40; 2009; 2004-2011; 10.1161/STROKEAHA.108.528299; citation_id=CR4
• Bioessays; Pathogenesis of CADASIL: transgenic and knock-out mice to probe function and dysfunction of the mutated gene, Notch3, in the cerebrovasculature; A Joutel; 33; 2011; 73-80; 10.1002/bies.201000093; citation_id=CR5

Terms in the title (6)： 遺伝 ,  脳 ,  血管疾患 ,  モデル ,  ヒトiPS細胞 ,  壁細胞