Art

J-GLOBAL ID：202002221544984237   Reference number：20A2056223

Prediction and Characterization of CYP3A4-mediated Metabolisms of Azole Fungicides: an Application of the Fused-grid Template* system

アゾール殺菌剤のCYP3A4介在性代謝の予測と特性評価:融合グリッドテンプレート^*システムの応用

Author (4)： Yamazoe Yasushi (Division of Drug Metabolism and Molecular Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aramaki-Aoba, Aoba-ku, Sendai 980-8578, Japan) ,  Yamazoe Yasushi (Division of Risk Assessment, National Institute of Health Sciences, Tonomachi 3-25-26, Kawasaki-ku, Kawasaki 210-9501, Japan) ,  Yamada Takashi (Division of Risk Assessment, National Institute of Health Sciences, Tonomachi 3-25-26, Kawasaki-ku, Kawasaki 210-9501, Japan) ,  Nagata Kiyoshi (Department of Environmental Health Science, Faculty of Pharmaceutical Sciences, School of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan)
Material： Food Safety (Web)  (Food Saf (Web))
Volume： 8  Issue： 2  Page： 34-51(J-STAGE)  Publication year： 2020 
JST Material Number： U0461A  ISSN： 2187-8404  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *cytochrome P450 ,...
Semi thesaurus term： *CYP3A4 ,...

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Author keywords (4)： Key word CYP3A4 inhibition and metabolism ,  triazole ,  imidazole ,  fungicide

JST classification (5)： Enzyme in general  (EB09010D) ,  Metabolism and biotransformasion of xenobiotics  (EJ02037P) ,  Drugs acting on pathogenic organisms in general  (GW17010H) ,  Pesticides to microorganisms  (FB06040Q) ,  Research methods in genetics  (EC01020N)

Substance index (12)： 1H-1,2,4-Triazole ,  Imidazole ,  R-115866 ,  Trovafloxacin ,  Fluconazole ,  Phosfluconazole ,  Voriconazole ,  Myclobutanil ,  Hexaconazole ,  Propiconazole ,  Metconazole ,  Cyproconazole

Reference (72)：

• 1. Warrilow AG, Parker JE, Kelly DE, Kelly SL. Azole affinity of sterol 14α-demethylase (CYP51) enzymes from Candida albicans and Homo sapiens. Antimicrob Agents Chemother. 2013; 57(3): 1352-1360. PMID:23274672, DOI:10.1128/AAC.02067-12
• 2. Trösken ER, Scholz K, Lutz RW, Völkel W, Zarn JA, Lutz WK. Comparative assessment of the inhibition of recombinant human CYP19 (aromatase) by azoles used in agriculture and as drugs for humans. Endocr Res. 2004; 30(3): 387-394. PMID:15554355, DOI:10.1081/ERC-200035093
• 3. Mast N, Zheng W, Stout CD, Pikuleva IA. Antifungal azoles: Structural insights into undesired tight binding cholesterol-metabolizing CYP46A1. Molecul Pharmacol. 2013; 84(1): 86-94. PMID:23604141, DOI:10.1124/mol.113.085902
• 4. Schwartz EL, Hallam S, Gallagher RE, Wiernik PH. Inhibition of all-trans-retinoic acid metabolism by fluconazole in vitro and in patients with acute promyelocytic leukemia. Biochem Pharmacol. 1995; 50(7): 923-928. PMID:7575674, DOI:10.1016/0006-2952(95)00213-J
• 5. Van Wauwe JP, Coene MC, Goossens J, Van Nijen G, Cools W, Lauwers W. Ketoconazole inhibits the in vitro and in vivo metabolism of all-trans-retinoic acid. J Pharmacol Exp Ther. 1988; 245(2): 718-722. PMID:3367313

Terms in the title (10)： アゾール ,  殺菌剤 ,  CYP3A4 ,  代謝 ,  予測 ,  特性評価 ,  融合 ,  グリッド ,  テンプレート ,  応用