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J-GLOBAL ID：202002222693974715   Reference number：20A1422165

Phos-tag-based micropipette-tip method for analysis of phosphomonoester-type impurities in synthetic oligonucleotides

合成オリゴヌクレオチド中のホスホモノエステル型不純物分析のためのPhosタグに基づくマイクロピペットチップ法【JST・京大機械翻訳】

Author (6)： Tsunehiro Masaya (Department of Functional Molecular Science, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan) ,  Tsunehiro Masaya (Analytical Research Department, Production Technology and Supply Chain Management Division, Mitsubishi Tanabe Pharma Corporation, Osaka, Japan) ,  Sasaki Kenji (Analytical Research Department, Production Technology and Supply Chain Management Division, Mitsubishi Tanabe Pharma Corporation, Osaka, Japan) ,  Kinoshita-Kikuta Emiko (Department of Functional Molecular Science, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan) ,  Kinoshita Eiji (Department of Functional Molecular Science, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan) ,  Koike Tohru (Department of Functional Molecular Science, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan)
Material： Journal of Chromatography B  (Journal of Chromatography B. Analytical Technologies in the Biomedical and Life Sciences)
Volume： 1151  Page： Null  Publication year： 2020 
JST Material Number： W0571A  ISSN： 1570-0232  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Various chromatographic techni...

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Thesaurus term： mass spectrometry ,  *impurity ,  ion pair ,  liquid chromatography ,  Chromatography ,  phosphate ,  phosphorylation ,  *oligonucleotide ,  affinity ,  characterization ,  LC-MS analysis ,  reversed phase ,  elution ,  reversed-phase liquid chromatography

Author keywords (5)： Oligonucleotide therapeutics ,  Liquid chromatography ,  Phos-tag technology ,  Mass spectrometry ,  Micropipette-tip method

JST classification (1)： Miscellaneous analytical methods of organic compounds  (CC08034J)

Terms in the title (4)： オリゴヌクレオチド ,  不純物 ,  分析 ,  タグ