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J-GLOBAL ID：202002223634721188   Reference number：20A0635939

Biological monitoring of o-toluidine in urine pretreated by an enzymatic deconjugation method

酵素的脱抱合法により前処理した尿中o-トルイジンの生物学的モニタリング

Author (5)： Eitaki Yoko (Department of Preventive Medicine and Public Health, Keio University School of Medicine) ,  Nakano Makiko (Department of Preventive Medicine and Public Health, Keio University School of Medicine) ,  Kawai Toshio (Kansai Occupational Health Technical Center) ,  Omae Kazuyuki (Department of Preventive Medicine and Public Health, Keio University School of Medicine) ,  Takebayashi Toru (Department of Preventive Medicine and Public Health, Keio University School of Medicine)
Material： Journal of Occupational Health  (J Occup Health)
Volume： 61  Issue： 5  Page： 349-357(J-STAGE)  Publication year： 2019 
JST Material Number： L2813A  ISSN： 1341-9145  CODEN： JOCHFV  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： chemical substance ,...

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Author keywords (6)： biological monitoring ,  high pressure liquid chromatography ,  hydrolysis ,  o-Toluidine ,  tandem mass spectrometry ,  β-Glucuronidase/arylsulfatase

JST classification (4)： Toxicity of organic compounds  (GZ02030Y) ,  Occupational health,industorial accidents  (GB05000S) ,  Applications of enzymes  (EB09100B) ,  Other pollutants  (SB05040W)

Substance index (3)： o-Toluidine ,  3-Methyl-4-aminophenol ,  2′-Methyl-4′-hydroxyacetanilide

Reference (14)：

• 1. International Agency for Research on Cancer (IARC). Chemical agents and related occupations. IARC Monogr Eval Carcinog Risks Hum. 2012;100(F):94-100.
• 2. Japan Society for Occupational Health. Occupational Exposure Limits Documentations (Brief summary), o-Toluidine (Carcinogenicity classification). https://www.sanei.or.jp/images/contents/328/o-Toluidine_Car.pdf. Published 2017. Accessed November 1, 2018.
• 3. American Conference of Governmental Industrial Hygienists (ACGIH). 2015 TLVs® and BEIs®. Cincinnati, OH: ACGIH; 2015.
• 4. Nakano M, Omae K, Takebayashi T, et al. An epidemic of bladder cancer: ten cases of bladder cancer in male Japanese workers exposed to ortho-toluidine. J Occup Health. 2018;60(4):307-311.
• 5. National Institute of Occupational Safety and Health, Japan. The inquest report for the industrial accident. A-2015-07 (in Japanese). http://www.jniosh.go.jp/publication/pdf/saigai_houkoku_2016_01.pdf#zoom=100. Published 2016. Accessed November 1, 2018.

Terms in the title (5)： 酵素 ,  抱合 ,  尿 ,  o-トルイジン ,  生物学的モニタリング