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J-GLOBAL ID：202002227193386463   Reference number：20A1517290

5-Fluorocytosine induces fetal skeletal malformations in rats by altering expression of Homeobox genes

5-フルオロシトシンはホメオボックス遺伝子の発現を変えることによりラットの胎児骨格奇形を誘発する

Author (8)： Kumamoto Takayuki (School of Pharmaceutical Sciences, Ohu University) ,  Senuma Mika (Laboratory of Safety Evaluation, Hatano Research Institute, Food and Drug Safety Center) ,  Todoroki Mai (Laboratory of Safety Evaluation, Hatano Research Institute, Food and Drug Safety Center) ,  Kumagai Fumiaki (Laboratory of Safety Evaluation, Hatano Research Institute, Food and Drug Safety Center) ,  Imai Hajime (School of Dentistry, Ohu University) ,  Suzuki Reiko (School of Dentistry, Ohu University) ,  Ogawa Tetsuo (Faculty of Medicine, Saitama Medical University) ,  Kuwagata Makiko (Division of Cellular and Molecular Toxicology, Center for Biological Safety and Research, National Institute of Health Science)
Material： Fundamental Toxicological Sciences (Web)  (Fundam Toxicol Sci (Web))
Volume： 7  Issue： 2  Page： 97-103(J-STAGE)  Publication year： 2020 
JST Material Number： U0596A  ISSN： 2189-115X  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *homeobox gene ,...
Semi thesaurus term： Hoxa11遺伝子 ,...

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Author keywords (4)： 5-FC (Flucytosine) ,  Homeobox ,  Thoracolumbar supernumerary rib ,  Digital malformation

JST classification (4)： Congenital diseases,deformities in general.  (GD03010V) ,  Toxicity of organic compounds  (GZ02030Y) ,  Gene expression  (EC02040Q) ,  Development(=generation)and differentiation  (EJ16020W)

Substance index (1)： Flucytosine

Reference (26)：

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• Burke, A.C., Nelson, C.E., Morgan, B.A. and Tabin, C. (1995): Hox genes and the evolution of vertebrate axial morphology. Development, 121, 333-346.
• Chen, F. and Capecchi, M.R. (1997): Targeted mutations in hoxa-9 and hoxb-9 reveal synergistic interactions. Dev. Biol., 181, 186-196.
• Chen, F. and Capecchi, M.R. (1999): Paralogous mouse Hox genes, Hoxa9, Hoxb9, and Hoxd9, function together to control development of the mammary gland in response to pregnancy. Proc. Natl. Acad. Sci. USA, 96, 541-546.

Terms in the title (8)： 5-フルオロシトシン ,  ホメオボックス遺伝子 ,  発現 ,  ラット ,  胎児 ,  骨格 ,  奇形 ,  誘発