Art

J-GLOBAL ID：202002227940079924   Reference number：20A0018930

N-Acetyl cysteine prevents activities of STAT3 inhibitors, Stattic and BP-1-102 independently of its antioxidant properties

N-アセチルシステインはその抗酸化特性と独立してSTAT3阻害剤,STATおよびBP-102の活性を妨げる【JST・京大機械翻訳】

Author (7)： Uchihara Yuki (Division of Hygienic Chemistry, Faculty of Pharmacy, Keio University, Minato-ku, Tokyo, Japan) ,  Ohe Tomoyuki (Division of Bioorganic and Medicinal Chemistry, Faculty of Pharmacy, Keio University, Minato-ku, Tokyo, Japan) ,  Mashino Tadahiko (Division of Bioorganic and Medicinal Chemistry, Faculty of Pharmacy, Keio University, Minato-ku, Tokyo, Japan) ,  Kidokoro Takayuki (Division of Hygienic Chemistry, Faculty of Pharmacy, Keio University, Minato-ku, Tokyo, Japan) ,  Tago Kenji (Division of Structural Biochemistry, Department of Biochemistry, Jichi Medical University, Shimotsuke-shi, Tochigi-ken, Japan) ,  Tamura Hiroomi (Division of Hygienic Chemistry, Faculty of Pharmacy, Keio University, Minato-ku, Tokyo, Japan) ,  Funakoshi-Tago Megumi (Division of Hygienic Chemistry, Faculty of Pharmacy, Keio University, Minato-ku, Tokyo, Japan)
Material： Pharmacological Reports  (Pharmacol Rep)
Volume： 71  Issue： 6  Page： 1067-1078  Publication year： 2019 
JST Material Number： A1528A  ISSN： 1734-1140  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Inhibitors for signal transduc...

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Thesaurus term： interaction ,  Cell Proliferation ,  phosphorylation ,  lymphoma ,  carcinogenicity ,  Cell Cycle ,  cytotoxicity ,  LC-MS analysis ,  addition product ,  *STAT transcription factor ,  fusion protein ,  Apoptosis ,  intracellular accumulation ,  nucleosome ,  nitrogen heterocyclic compound ,  aromatic compound ,  vic-polynitrogen compound

Author keywords (5)： N-Acetyl cysteine ,  STAT3 inhibitor ,  Stattic ,  BP-1-102 ,  NPM-ALK

JST classification (4)： Cell physiology in general  (EF02010S) ,  Plant biochemistry  (EH01050J) ,  Basic research of pharmacology of crude drugs  (GX06020J) ,  Basic research of psychotropic drugs  (GW03100Y)

Substance index (1)： Edaravone

Terms in the title (5)： N-アセチルシステイン ,  抗酸化特性 ,  STAT3阻害剤 ,  Stat ,  活性