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J-GLOBAL ID：202002229315021292   Reference number：20A1174987

Cryo-EM structures of the human volume-regulated anion channel LRRC8

ヒト容積調節アニオンチャンネルLRRC8の低温EM構造【JST・京大機械翻訳】

Author (21)： Kasuya Go (Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo-ku, Tokyo, Japan) ,  Kasuya Go (Pharmaceuticals and Medical Devices Agency, Tokyo, Japan) ,  Nakane Takanori (Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo-ku, Tokyo, Japan) ,  Nakane Takanori (MRC Laboratory of Molecular Biology, Cambridge, UK) ,  Yokoyama Takeshi (Laboratory for Protein Functional and Structural Biology, RIKEN Center for Biosystems Dynamics Research, Yokohama-shi, Kanagawa, Japan) ,  Jia Yanyan (State Key Laboratory of Medical Neurobiology, Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center of Genetics and Development, Department of Physiology and Biophysics, School of Life Sciences, Fudan University, Yangpu District, Shanghai, China) ,  Inoue Masato (Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan) ,  Watanabe Kengo (Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan) ,  Nakamura Ryoki (Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo-ku, Tokyo, Japan) ,  Nishizawa Tomohiro (Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo-ku, Tokyo, Japan) ,  Kusakizako Tsukasa (Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo-ku, Tokyo, Japan) ,  Tsutsumi Akihisa (Department of Cell Biology and Anatomy, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan) ,  Yanagisawa Haruaki (Department of Cell Biology and Anatomy, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan) ,  Dohmae Naoshi (RIKEN, Global Research Cluster, Wako-shi, Saitama, Japan) ,  Hattori Motoyuki (State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Physiology and Biophysics, School of Life Sciences, Fudan University, Yangpu District, Shanghai, China) ,  Ichijo Hidenori (Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan) ,  Yan Zhiqiang (State Key Laboratory of Medical Neurobiology, Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center of Genetics and Development, Department of Physiology and Biophysics, School of Life Sciences, Fudan University, Yangpu District, Shanghai, China) ,  Kikkawa Masahide (Department of Cell Biology and Anatomy, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan) ,  Shirouzu Mikako (Laboratory for Protein Functional and Structural Biology, RIKEN Center for Biosystems Dynamics Research, Yokohama-shi, Kanagawa, Japan) ,  Ishitani Ryuichiro (Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo-ku, Tokyo, Japan) ,  Nureki Osamu (Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo-ku, Tokyo, Japan)
Material： Nature Structural & Molecular Biology  (Nat Struct Mol Biol)
Volume： 25  Issue： 9  Page： 797-804  Publication year： 2018 
JST Material Number： W0637A  ISSN： 1545-9993  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Abstract/Point： Abstract: Maintenance of cell ...

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Thesaurus term： topology ,  Osmotic Pressure ,  *low temperature ,  electric charge ,  steric conformation ,  swelling ,  Proteins ,  human ,  *anion ,  structural phase transition ,  hexamer ,  *anion channel ,  aliphatic amine ,  aliphatic carboxylic acid ,  branched-chain amino acid
Semi thesaurus term： ゲーティング ,  残基 , 【Automatic Indexing@JST】

JST classification (2)： Molecular structure  (EB03020Y) ,  Biological function  (EB03040U)

Substance index (1)： Leucine

Terms in the title (5)： ヒト ,  容積調節 ,  アニオンチャンネル ,  低温 ,  EM