Art

J-GLOBAL ID：202002231858674977   Reference number：20A0447136

Midazolam Irreversibly Inhibits CYP3A4

ミダゾラムはCYP3A4を不可逆的に阻害する

Author (5)： IWASE Yumiko (Yokohama Univ. Pharmacy, Kanagawa, JPN) ,  OKUDAIRA Kazuho (Yokohama Univ. Pharmacy, Kanagawa, JPN) ,  NISHI Koji (Sojo Univ., Kumamoto, JPN) ,  ITHO Tomoo (Kitasato Univ., Tokyo, JPN) ,  YUMITA Nagahiko (Yokohama Univ. Pharmacy, Kanagawa, JPN)
Material： 応用薬理  (Pharmacometrics)
Volume： 97  Issue： 5-6  Page： 97-103  Publication year： Jan. 27, 2020 
JST Material Number： S0617A  ISSN： 0300-8533  CODEN： OYYAA2  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： drug metabolizing enzyme ,...
Semi thesaurus term： Mechanism-based inhibition ,...

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JST classification (2)： Basic biopharmacy  (GY01021U) ,  Interactions of drugs  (GV01070X)

Substance index (3)： Midazolam ,  Troleandomycin ,  Triazolam

Reference (29)：

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• Fontana, E., Dansette, PM. and Poli, SM. (2005) Cytochrome p450 enzymes mechanism-based inhibitors: common sub-structures and reactivity, Curr. Drug Metab., 6, 413-454.
• Guengerich, FP. (1997) Role of cytochrome P450 enzymes in drug-drug interactions, Adv. Pharmacol., 43, 7-35.
• Guengerich, FP. (1999) Cytochrome P-450 3A4: regulation and role in drug metabolism, Annu. Rev. Pharmacol. Toxicol., 39, 1-17.

Terms in the title (4)： ミダゾラム ,  CYP3A4 ,  不可逆 ,  阻害