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J-GLOBAL ID：202002231928934633   Reference number：20A0459258

Structural instability and divergence from conserved residues underlie intracellular retention of mammalian odorant receptors

保存された残基からの構造不安定性と分岐は哺乳類の匂い物質受容体の細胞内保持の基礎となる【JST・京大機械翻訳】

Author (16)： Ikegami Kentaro (Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710) ,  Ikegami Kentaro (Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, Tokyo 184-8588, Japan) ,  de March Claire A. (Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710) ,  Nagai Maira H. (Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710) ,  Nagai Maira H. (Department of Biochemistry, Universidade de Sao Paulo, Sao Paulo, 05508-000, Brazil) ,  Ghosh Soumadwip (Department of Computational and Quantitative Medicine, Beckman Research Institute of the City of Hope, Duarte, CA 91010) ,  Do Matthew (Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710) ,  Sharma Ruchira (Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710) ,  Bruguera Elise S. (Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710) ,  Lu Yueyang Eric (Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710) ,  Fukutani Yosuke (Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710) ,  Fukutani Yosuke (Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, Tokyo 184-8588, Japan) ,  Vaidehi Nagarajan (Department of Computational and Quantitative Medicine, Beckman Research Institute of the City of Hope, Duarte, CA 91010) ,  Yohda Masafumi (Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, Tokyo 184-8588, Japan) ,  Matsunami Hiroaki (Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710) ,  Matsunami Hiroaki (Department of Neurobiology, Duke Institute for Brain Sciences, Duke University, Durham, NC 27710)
Material： Proceedings of the National Academy of Sciences of the United States of America  (PNAS)
Volume： 117  Issue： 6  Page： 2957-2967  Publication year： 2020 
JST Material Number： D0387A  ISSN： 0027-8424  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Mammalian odorant receptors ar...

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Thesaurus term： *receptor ,  screening (inspection) ,  sensory nerve ,  cilium ,  Endoplasmic Reticulum ,  *smell substance ,  Mutation ,  electrostatic capacity ,  instability ,  *Mammalia ,  olfactory cells ,  Computer Simulation ,  sense of smell ,  Point Mutation ,  in silico ,  *Vertebrata ,  olfactory organ ,  cell ,  computer application ,  utilization
Semi thesaurus term： *残基 , 【Automatic Indexing@JST】

Author keywords (3)： GPCR ,  protein trafficking ,  olfaction

JST classification (2)： Receptors on cell membrane  (EF04030C) ,  Cell physiology in general  (EF02010S)

Terms in the title (8)： 保存 ,  残基 ,  構造不安定性 ,  分岐 ,  哺乳類 ,  匂い物質 ,  受容体 ,  基礎