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J-GLOBAL ID：202002232089958465   Reference number：20A2658982

The Oncogenic PRL Protein Causes Acid Addiction of Cells by Stimulating Lysosomal Exocytosis

発癌性PRL蛋白質はリソソームエキソサイトーシスを刺激することにより細胞の酸依存を引き起こす【JST・京大機械翻訳】

Author (6)： Funato Yosuke (Department of Cellular Regulation, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan) ,  Yoshida Atsushi (Department of Cellular Regulation, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan) ,  Hirata Yusuke (Laboratory of Health Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi 980-8578, Japan) ,  Hashizume Osamu (Department of Cellular Regulation, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan) ,  Yamazaki Daisuke (Department of Cellular Regulation, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan) ,  Miki Hiroaki (Department of Cellular Regulation, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan)
Material： Developmental Cell  (Dev Cell)
Volume： 55  Issue： 4  Page： 387-397.e8  Publication year： 2020 
JST Material Number： W1692A  ISSN： 1534-5807  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Extracellular pH is usually ma...

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Thesaurus term： optimization ,  lathe turning ,  tumor cell ,  carcinogenicity ,  phosphatase ,  cultured cell ,  *lysosome ,  acidity (property) ,  *Exocytosis ,  molecular switch ,  microenvironment ,  multicellular organism ,  Caenorhabditis elegans ,  Cas9 protein ,  modification ,  switch ,  Rhabditida ,  invertebrate
Semi thesaurus term： Caenorhabditis elegans ,  悪性腫瘍 ,  Cas9 , 【Automatic Indexing@JST】

Author keywords (7)： acid addiction ,  tumor microenvironment ,  lysosomal exocytosis ,  phosphatase of regenerating liver ,  PRL ,  transient receptor potential mucolipin ,  TRPML

JST classification (2)： Biological function  (EB03040U) ,  Cell physiology in general  (EF02010S)

Terms in the title (6)： 発癌性 ,  PRL ,  蛋白質 ,  刺激 ,  細胞 ,  酸