Art

J-GLOBAL ID：202002235056750434   Reference number：20A0700780

Post-translational Modifications of Therapeutic Monoclonal Antibodies [Part 4]

モノクローナル抗体医薬品の翻訳後修飾[その4]

Author (1)： NIIMI SHINGO (日本化薬)
Material： 医薬品医療機器レギュラトリーサイエンス  (Pharmaceutical and Medical Device Regulatory Science)
Volume： 51  Issue： 3  Page： 154-163  Publication year： Mar. 10, 2020 
JST Material Number： F0456B  ISSN： 1884-6076  CODEN： IIKRA9  Document type： Article
Article type： 文献レビュー  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： post-translational modification ,...
Semi thesaurus term： Aspartic acid residue

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JST classification (2)： Biochemistry of antigens,antibodies,complements  (ED04020L) ,  Physicochemical pharmacy in general  (GV01010J)

Reference (60)：

• 新見伸吾. モノクローナル抗体医薬品の翻訳後修飾[その3].医薬品医療機器レギュラトリーサイエンス. 2020,51(2),p.89-95.
• Cacia, J.; Keck, R.; Presta, L.G.; Frenz, J. Isomerization of an aspartic acid residue in the complementarity-determining regions of a recombinant antibody to human IgE: identification and effect on binding affinity. Biochemistry. 1996, 35(6), p.1897-1903.
• Harris, R.J.; Kabakoff, B.; Macchi, F.D.; Shen, F.J.; Kwong, M.; Andya, J.D.; Shire, S.J.; Bjork, N.; Totpal, K.; Chen, A.B. Identification of multiple sources of charge heterogeneity in a recombinant antibody. J Chromatogr B Biomed Sci Appl. 2001, 752(2), p.233-245.
• Huang, L.; Lu, J.; Wroblewski, V.J.; Beals, J.M.; Riggin, R.M. In vivo deamidation characterization of monoclonal antibody by LC/MS/MS. Anal Chem. 2005, 77(5), p.1432-1439.
• Lyubarskaya, Y.; Houde, D.; Woodard, J.; Murphy, D.; Mhatre, R. Analysis of recombinant monoclonal antibody isoforms by electrospray ionization mass spectrometry as a strategy for streamlining characterization of recombinant monoclonal antibody charge heterogeneity. Anal Biochem. 2006, 348(1), p.24-39.

Terms in the title (3)： モノクローナル抗体 ,  医薬品 ,  翻訳後修飾