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J-GLOBAL ID：202002235523817086   Reference number：20A0553586

CYP2D6 genotyping analysis and functional characterization of novel allelic variants in a Ni-Vanuatu and Kenyan population by assessing dextromethorphan O-demethylation activity

デキストロメトルファンO-脱メチル化活性を評価することによるバヌアツ原住現地人とケニア人の集団における新規対立遺伝子変異体のCYP2D6遺伝子型解析と機能的特性化

Author (21)： Gutierrez Rico Evelyn Marie (Laboratory of Pharmacotherapy of Life-Style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan) ,  Kikuchi Aoi (Laboratory of Pharmacotherapy of Life-Style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan) ,  Saito Takahiro (Laboratory of Pharmacotherapy of Life-Style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan) ,  Kumondai Masaki (Laboratory of Pharmacotherapy of Life-Style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan) ,  Hishinuma Eiji (Laboratory of Pharmacotherapy of Life-Style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan) ,  Hishinuma Eiji (Advanced Research Center for Innovations in Next-Generation Medicine, Tohoku University, Sendai, 980-8575, Japan) ,  Hishinuma Eiji (Tohoku Medical Megabank Organization, Tohoku University, Sendai, 980-8575, Japan) ,  Kaneko Akira (Department of Parasitology and Research Center for Infectious Disease Sciences, Graduate School of Medicine, Osaka City University, Osaka 545-8585, Japan) ,  Kaneko Akira (Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 17177 Stockholm, Sweden) ,  Chan Chim Wai (Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 17177 Stockholm, Sweden) ,  Gitaka Jesse (Mount Kenya University, Thika, Kenya) ,  Nakayoshi Tomoki (Faculty of Pharmacy, Meijo University, Nagoya 468-8503, Japan) ,  Oda Akifumi (Faculty of Pharmacy, Meijo University, Nagoya 468-8503, Japan) ,  Saito Sakae (Tohoku Medical Megabank Organization, Tohoku University, Sendai, 980-8575, Japan) ,  Hirasawa Noriyasu (Laboratory of Pharmacotherapy of Life-Style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan) ,  Hirasawa Noriyasu (Advanced Research Center for Innovations in Next-Generation Medicine, Tohoku University, Sendai, 980-8575, Japan) ,  Hirasawa Noriyasu (Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai 980-8574, Japan) ,  Hiratsuka Masahiro (Laboratory of Pharmacotherapy of Life-Style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan) ,  Hiratsuka Masahiro (Advanced Research Center for Innovations in Next-Generation Medicine, Tohoku University, Sendai, 980-8575, Japan) ,  Hiratsuka Masahiro (Tohoku Medical Megabank Organization, Tohoku University, Sendai, 980-8575, Japan) ,  Hiratsuka Masahiro (Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai 980-8574, Japan)
Material： Drug Metabolism and Pharmacokinetics (Web)  (Drug Metab Pharmacokinet (Web))
Volume： 35  Issue： 1  Page： 89-101  Publication year： 2020 
JST Material Number： U0705A  ISSN： 1347-4367  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： human(primates) ,...
Semi thesaurus term： 293FT cell ,...

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Author keywords (6)： Cytochrome P450 ,  CYP2D6 ,  Genetic polymorphism ,  Population pharmacogenomics ,  Kenya ,  Vanuatu

JST classification (1)： Genetic variation  (EC01030Y)

Substance index (1)： Dextromethorphan

Terms in the title (12)： デキストロメトルファン ,  脱メチル化 ,  活性 ,  評価 ,  バヌアツ ,  現地 ,  ケニア ,  集団 ,  対立遺伝子変異 ,  CYP2D6 ,  遺伝子型解析 ,  特性化